Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate

To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation (Pik3ca(H1047R)) and deletion of Pten. Using mouse embryonic fibroblast (MEF) models...

Descripción completa

Detalles Bibliográficos
Autores principales: Moniz, Larissa S., Surinova, Silvia, Ghazaly, Essam, Velasco, Lorena Gonzalez, Haider, Syed, Rodríguez-Prados, Juan Carlos, Berenjeno, Inma M., Chelala, Claude, Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216349/
https://www.ncbi.nlm.nih.gov/pubmed/28059163
http://dx.doi.org/10.1038/srep39985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216349/
https://www.ncbi.nlm.nih.gov/pubmed/28059163
http://dx.doi.org/10.1038/srep39985

Ejemplares similares