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NMR reveals a dynamic allosteric pathway in thrombin

Although serine proteases are found ubiquitously in both eukaryotes and prokaryotes, and they comprise the largest of all of the peptidase families, their dynamic motions remain obscure. The backbone dynamics of the coagulation serine protease, apo-thrombin (S195M-thrombin), were compared to the sub...

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Detalles Bibliográficos
Autores principales:	Handley, Lindsey D., Fuglestad, Brian, Stearns, Kyle, Tonelli, Marco, Fenwick, R. Bryn, Markwick, Phineus R. L., Komives, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216386/ https://www.ncbi.nlm.nih.gov/pubmed/28059082 http://dx.doi.org/10.1038/srep39575

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