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Scaling of titanium implants entrains inflammation-induced osteolysis
With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216395/ https://www.ncbi.nlm.nih.gov/pubmed/28059080 http://dx.doi.org/10.1038/srep39612 |
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author | Eger, Michal Sterer, Nir Liron, Tamar Kohavi, David Gabet, Yankel |
author_facet | Eger, Michal Sterer, Nir Liron, Tamar Kohavi, David Gabet, Yankel |
author_sort | Eger, Michal |
collection | PubMed |
description | With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis. The number of released particles and their chemical composition and nanotopography had a significant effect on the inflammatory response. Sandblasted surfaces released the highest number of particles with the greatest nanoroughness properties. Particles from sandblasted/acid-etched discs induced a milder inflammatory response than those from sandblasted discs but a stronger inflammatory response than those from machined discs. Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants. |
format | Online Article Text |
id | pubmed-5216395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52163952017-01-10 Scaling of titanium implants entrains inflammation-induced osteolysis Eger, Michal Sterer, Nir Liron, Tamar Kohavi, David Gabet, Yankel Sci Rep Article With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis. The number of released particles and their chemical composition and nanotopography had a significant effect on the inflammatory response. Sandblasted surfaces released the highest number of particles with the greatest nanoroughness properties. Particles from sandblasted/acid-etched discs induced a milder inflammatory response than those from sandblasted discs but a stronger inflammatory response than those from machined discs. Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants. Nature Publishing Group 2017-01-06 /pmc/articles/PMC5216395/ /pubmed/28059080 http://dx.doi.org/10.1038/srep39612 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Eger, Michal Sterer, Nir Liron, Tamar Kohavi, David Gabet, Yankel Scaling of titanium implants entrains inflammation-induced osteolysis |
title | Scaling of titanium implants entrains inflammation-induced osteolysis |
title_full | Scaling of titanium implants entrains inflammation-induced osteolysis |
title_fullStr | Scaling of titanium implants entrains inflammation-induced osteolysis |
title_full_unstemmed | Scaling of titanium implants entrains inflammation-induced osteolysis |
title_short | Scaling of titanium implants entrains inflammation-induced osteolysis |
title_sort | scaling of titanium implants entrains inflammation-induced osteolysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216395/ https://www.ncbi.nlm.nih.gov/pubmed/28059080 http://dx.doi.org/10.1038/srep39612 |
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