Prediction of N-Methyl-D-Aspartate Receptor GluN1-Ligand Binding Affinity by a Novel SVM-Pose/SVM-Score Combinatorial Ensemble Docking Scheme

The glycine-binding site of the N-methyl-D-aspartate receptor (NMDAR) subunit GluN1 is a potential pharmacological target for neurodegenerative disorders. A novel combinatorial ensemble docking scheme using ligand and protein conformation ensembles and customized support vector machine (SVM)-based m...

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Detalles Bibliográficos
Autores principales: Leong, Max K., Syu, Ren-Guei, Ding, Yi-Lung, Weng, Ching-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216401/
https://www.ncbi.nlm.nih.gov/pubmed/28059133
http://dx.doi.org/10.1038/srep40053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216401/
https://www.ncbi.nlm.nih.gov/pubmed/28059133
http://dx.doi.org/10.1038/srep40053

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