Cargando…

A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter

The dopamine transporter (DAT) belongs to the neurotransmitter:sodium symporter (NSS) family of membrane proteins that are responsible for reuptake of neurotransmitters from the synaptic cleft to terminate a neuronal signal and enable subsequent neurotransmitter release from the presynaptic neuron....

Descripción completa

Detalles Bibliográficos
Autores principales:	Razavi, Asghar M., Khelashvili, George, Weinstein, Harel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216462/ https://www.ncbi.nlm.nih.gov/pubmed/28059145 http://dx.doi.org/10.1038/srep40076

Ejemplares similares

How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties
por: Razavi, Asghar M., et al.
Publicado: (2018)

Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh
por: Stolzenberg, Sebastian, et al.
Publicado: (2012)

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP(2)-Regulated Dynamics of the N-Terminus
por: Khelashvili, George, et al.
Publicado: (2015)

Protein Diffusion on Charged Membranes: A Dynamic Mean-Field Model Describes Time Evolution and Lipid Reorganization
por: Khelashvili, George, et al.
Publicado: (2008)

Elucidating the Mechanism of Membrane Destabilization by the Preferred Modes of Insertion of the Sars-Cov2 Fusion Peptide
por: Khelashvili, George, et al.
Publicado: (2021)

A partially-open inward-facing intermediate conformation of LeuT is associated with Na(+) release and substrate transport
por: Terry, Daniel S., et al.
Publicado: (2018)

Phosphatidylinositol 4,5-Biphosphate (PIP(2)) Lipids Regulate the Phosphorylation of Syntaxin N-Terminus by Modulating Both Its Position and Local Structure
por: Khelashvili, George, et al.
Publicado: (2012)

Not Just an Oil Slick: How the Energetics of Protein-Membrane Interactions Impacts the Function and Organization of Transmembrane Proteins
por: Mondal, Sayan, et al.
Publicado: (2014)

The permeation of potassium ions through the lipid scrambling path of the membrane protein nhTMEM16
por: Cheng, Xiaolu, et al.
Publicado: (2022)

The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase
por: Khelashvili, George, et al.
Publicado: (2022)

Optimal Dimensionality Reduction of Multistate Kinetic and Markov-State Models
por: Hummer, Gerhard, et al.
Publicado: (2014)

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles
por: LeVine, Michael V., et al.
Publicado: (2016)

The Substrate-Driven Transition to an Inward-Facing Conformation in the Functional Mechanism of the Dopamine Transporter
por: Shan, Jufang, et al.
Publicado: (2011)

Ca(2+)-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide
por: Khelashvili, George, et al.
Publicado: (2021)

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
por: Condon, Mark D., et al.
Publicado: (2019)

Linking Exponential Components to Kinetic States in Markov Models for Single-Channel Gating
por: Shelley, Christopher, et al.
Publicado: (2008)

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor
por: LeVine, Michael V., et al.
Publicado: (2019)

Mechanism of the Association between Na(+) Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
por: Stolzenberg, Sebastian, et al.
Publicado: (2015)

Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT(2A) Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties
por: Shan, Jufang, et al.
Publicado: (2012)

A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs
por: Plante, Ambrose, et al.
Publicado: (2019)

Transport domain unlocking sets the uptake rate of an aspartate transporter
por: Akyuz, Nurunisa, et al.
Publicado: (2015)

Combination of Markov State Models and Kinetic Networks for the Analysis of Molecular Dynamics Simulations of Peptide Folding
por: Radford, Isolde H., et al.
Publicado: (2011)

Nonlinear Markov Processes and Kinetic Equations
por: Kolokoltsov, Vassili N
Publicado: (2010)

Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization
por: Johner, Niklaus, et al.
Publicado: (2014)

Low sodium diet for gastric cancer prevention in the United States: Results of a Markov model
por: Kim, Judith, et al.
Publicado: (2020)

Thermodynamics and kinetics of the amyloid-β peptide revealed by Markov state models based on MD data in agreement with experiment
por: Paul, Arghadwip, et al.
Publicado: (2021)

A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms
por: Balbi, Pietro, et al.
Publicado: (2017)

Membrane Driven Spatial Organization of GPCRs
por: Mondal, Sayan, et al.
Publicado: (2013)

Phosphatidylinositol phosphates modulate interactions between the StarD4 sterol trafficking protein and lipid membranes
por: Zhang, Xiaoxue, et al.
Publicado: (2022)

Use of Paramagnetic (19)F NMR to Monitor Domain Movement in a Glutamate Transporter
por: Huang, Yun, et al.
Publicado: (2020)

Why GPCRs behave differently in cubic and lamellar lipidic mesophases
por: Khelashvili, George, et al.
Publicado: (2012)

A Functional Selectivity Mechanism at the Serotonin-2A GPCR Involves Ligand-Dependent Conformations of Intracellular Loop 2
por: Perez-Aguilar, Jose Manuel, et al.
Publicado: (2014)

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
por: Lee, Byoung-Cheol, et al.
Publicado: (2018)

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca(2+)-bound nhTMEM16
por: Khelashvili, George, et al.
Publicado: (2019)

The Kinetics of Sodium Transport in the Toad Bladder : I. Determination of the transport pool
por: Finn, Arthur L., et al.
Publicado: (1971)

Global and Kinetic Profiles of Substrate Diffusion in Candida antarctica Lipase B: Molecular Dynamics with the Markov-State Model
por: Lu, Chenlin, et al.
Publicado: (2020)

Implementation of the Freely Jointed Chain Model to Assess Kinetics and Thermodynamics of Thermosensitive Coil–Globule Transition by Markov States
por: Quoika, Patrick K., et al.
Publicado: (2021)

The Membrane Protein LeuT in Micellar Systems: Aggregation Dynamics and Detergent Binding to the S2 Site
por: Khelashvili, George, et al.
Publicado: (2013)

Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release
por: Keighron, Jacqueline D., et al.
Publicado: (2023)

Building Markov state models with solvent dynamics
por: Gu, Chen, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ta7o14lgej9bh350ad4cnrvs3o