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Therapeutic vaccine targeting Epstein-Barr virus latent protein, LMP1, suppresses LMP1-expressing tumor growth and metastasis in vivo

BACKGROUND: In endemic area, nasopharyngeal carcinoma (NPC) tumor cells harbor EBV latent infection and expresses viral antigens such as EBNA1, LMP1 and LMP2. In this study, we established a NPC-mimicry animal model and assessed the therapeutic potential of LMP1 vaccine. METHODS: Animal models were...

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Detalles Bibliográficos
Autores principales:	Lin, Mei-Chun, Lin, Yong-Chong, Chen, Syue-Ting, Young, Tai-Horng, Lou, Pei-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216543/ https://www.ncbi.nlm.nih.gov/pubmed/28056887 http://dx.doi.org/10.1186/s12885-016-3027-1

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