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Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection
BACKGROUND: The study was designed to investigate the roles of endometrial thickness (EMT) at the day of human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population. METHODS: This retrospective cohort study included 9,952 patients undergoing their first IVF/...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216548/ https://www.ncbi.nlm.nih.gov/pubmed/28056983 http://dx.doi.org/10.1186/s12958-016-0222-5 |
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author | Ma, Ning-Zhao Chen, Lei Dai, Wei Bu, Zhi-Qin Hu, Lin-Li Sun, Ying-Pu |
author_facet | Ma, Ning-Zhao Chen, Lei Dai, Wei Bu, Zhi-Qin Hu, Lin-Li Sun, Ying-Pu |
author_sort | Ma, Ning-Zhao |
collection | PubMed |
description | BACKGROUND: The study was designed to investigate the roles of endometrial thickness (EMT) at the day of human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population. METHODS: This retrospective cohort study included 9,952 patients undergoing their first IVF/ICSI with autologous oocytes from January 2011 to January 2015. Patients were divided into three groups based on the EMT (group A:≤8 mm; group B: 9–14 mm and group C:≥15 mm). Live birth rate (LBR), clinical pregnancy rate (CPR), early miscarriage rate (EMR), and ectopic pregnancy rate (EPR) were analyzed. Additionally, the live birth rate was analyzed for patients with single or double gestational sacs. RESULTS: Significant differences (p < 0.05) were detected in the LBRs (30.38%, 45.73% and 54.55% for groups A, B, and C, respectively), CPRs (38.57%, 55.04% and 64.32%, respectively), and EPRs (5.58%, 3.48% and 2.19%, respectively), with thicker endometrial thickness favoring all three parameters. However, no differences were found in the EMRs among the three groups (15.64%, 13.44% and 13.05%, respectively, p > 0.05). After adjusting for female age, body mass index (BMI) and endometrial pattern, the multivariate logistic regression analysis demonstrated that the associations between EMT and LBR (adjusted OR: 2.645; 95% CI 2.020–3.464; p < 0.01), CPR (adjusted OR 2.693 95% CI 2.012–3.605 p < 0.01), and EPR (adjusted OR: 0.298 95% CI 0.101–0.713; p < 0.05) were significant. Additionally, live birth rates in the double gestational sac group were different (p < 0.05) among patients with different EMT (72.73%, 87.28%, and 87.36%, respectively), whereas no difference was found in the single gestational sac group. In the double gestational sac group, LBR was positively correlated with increasing endometrial thickness only in patients with twin pregnancies but not in patients with singletons. CONCLUSIONS: Our study shows that endometrial thickness at the day of hCG administration has an effect on LBR, CPR and EPR, with all three parameters increasing with the EMT. Furthermore, successful twin pregnancies are associated with a thicker endometrium. |
format | Online Article Text |
id | pubmed-5216548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52165482017-01-09 Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection Ma, Ning-Zhao Chen, Lei Dai, Wei Bu, Zhi-Qin Hu, Lin-Li Sun, Ying-Pu Reprod Biol Endocrinol Research BACKGROUND: The study was designed to investigate the roles of endometrial thickness (EMT) at the day of human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population. METHODS: This retrospective cohort study included 9,952 patients undergoing their first IVF/ICSI with autologous oocytes from January 2011 to January 2015. Patients were divided into three groups based on the EMT (group A:≤8 mm; group B: 9–14 mm and group C:≥15 mm). Live birth rate (LBR), clinical pregnancy rate (CPR), early miscarriage rate (EMR), and ectopic pregnancy rate (EPR) were analyzed. Additionally, the live birth rate was analyzed for patients with single or double gestational sacs. RESULTS: Significant differences (p < 0.05) were detected in the LBRs (30.38%, 45.73% and 54.55% for groups A, B, and C, respectively), CPRs (38.57%, 55.04% and 64.32%, respectively), and EPRs (5.58%, 3.48% and 2.19%, respectively), with thicker endometrial thickness favoring all three parameters. However, no differences were found in the EMRs among the three groups (15.64%, 13.44% and 13.05%, respectively, p > 0.05). After adjusting for female age, body mass index (BMI) and endometrial pattern, the multivariate logistic regression analysis demonstrated that the associations between EMT and LBR (adjusted OR: 2.645; 95% CI 2.020–3.464; p < 0.01), CPR (adjusted OR 2.693 95% CI 2.012–3.605 p < 0.01), and EPR (adjusted OR: 0.298 95% CI 0.101–0.713; p < 0.05) were significant. Additionally, live birth rates in the double gestational sac group were different (p < 0.05) among patients with different EMT (72.73%, 87.28%, and 87.36%, respectively), whereas no difference was found in the single gestational sac group. In the double gestational sac group, LBR was positively correlated with increasing endometrial thickness only in patients with twin pregnancies but not in patients with singletons. CONCLUSIONS: Our study shows that endometrial thickness at the day of hCG administration has an effect on LBR, CPR and EPR, with all three parameters increasing with the EMT. Furthermore, successful twin pregnancies are associated with a thicker endometrium. BioMed Central 2017-01-05 /pmc/articles/PMC5216548/ /pubmed/28056983 http://dx.doi.org/10.1186/s12958-016-0222-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Ma, Ning-Zhao Chen, Lei Dai, Wei Bu, Zhi-Qin Hu, Lin-Li Sun, Ying-Pu Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection |
title | Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection |
title_full | Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection |
title_fullStr | Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection |
title_full_unstemmed | Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection |
title_short | Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection |
title_sort | influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216548/ https://www.ncbi.nlm.nih.gov/pubmed/28056983 http://dx.doi.org/10.1186/s12958-016-0222-5 |
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