Cargando…
The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans
BACKGROUND/AIMS: Little research has been done to evaluate the effect of stress in exacerbating the symptoms associated with gastroesophageal reflux (GER). We aimed to investigate the effect of acute stress on esophageal motility and GER parameters in healthy volunteers. METHODS: A total of 10 (M:F...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Neurogastroenterology and Motility
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216637/ https://www.ncbi.nlm.nih.gov/pubmed/28049863 http://dx.doi.org/10.5056/jnm16119 |
_version_ | 1782491951134670848 |
---|---|
author | Lee, Hong Sub Noh, Chung Kyun Lee, Kwang Jae |
author_facet | Lee, Hong Sub Noh, Chung Kyun Lee, Kwang Jae |
author_sort | Lee, Hong Sub |
collection | PubMed |
description | BACKGROUND/AIMS: Little research has been done to evaluate the effect of stress in exacerbating the symptoms associated with gastroesophageal reflux (GER). We aimed to investigate the effect of acute stress on esophageal motility and GER parameters in healthy volunteers. METHODS: A total of 10 (M:F = 8:2, median age 34 years-old) healthy volunteers without any recurrent gastrointestinal symptoms participated in this study. They underwent esophageal high-resolution manometry with 10 wet swallows (Experiment I) and esophageal impedance-pH monitoring (Experiment II) in the basal period and in the stress period. In the stress period, either real stress or sham stress was given in a randomized cross-over design. The stress scores, symptom severity, and pulse rates were measured. RESULTS: The stress scores and the severity of nausea were significantly greater under real stress, compared with sham stress. The percentages of weak, failed, rapid, premature, and hyper-contractile contractions were not significantly altered during real stress and during sham stress, compared with the basal period. The median resting pressure of the lower esophageal sphincter and distal contractile integral of esophageal contractions did not differ in the stress period, compared with the basal period. Contractile front velocity and distal latency of esophageal peristaltic contractions were significantly changed during real stress, which was not observed during sham stress. GER parameters were not significantly altered during real stress and during sham stress. CONCLUSION: Although acute auditory and visual stress seems to affect esophageal body motility, it does not induce significant motor abnormalities or increase GER in healthy humans. |
format | Online Article Text |
id | pubmed-5216637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Society of Neurogastroenterology and Motility |
record_format | MEDLINE/PubMed |
spelling | pubmed-52166372017-01-18 The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans Lee, Hong Sub Noh, Chung Kyun Lee, Kwang Jae J Neurogastroenterol Motil Original Article BACKGROUND/AIMS: Little research has been done to evaluate the effect of stress in exacerbating the symptoms associated with gastroesophageal reflux (GER). We aimed to investigate the effect of acute stress on esophageal motility and GER parameters in healthy volunteers. METHODS: A total of 10 (M:F = 8:2, median age 34 years-old) healthy volunteers without any recurrent gastrointestinal symptoms participated in this study. They underwent esophageal high-resolution manometry with 10 wet swallows (Experiment I) and esophageal impedance-pH monitoring (Experiment II) in the basal period and in the stress period. In the stress period, either real stress or sham stress was given in a randomized cross-over design. The stress scores, symptom severity, and pulse rates were measured. RESULTS: The stress scores and the severity of nausea were significantly greater under real stress, compared with sham stress. The percentages of weak, failed, rapid, premature, and hyper-contractile contractions were not significantly altered during real stress and during sham stress, compared with the basal period. The median resting pressure of the lower esophageal sphincter and distal contractile integral of esophageal contractions did not differ in the stress period, compared with the basal period. Contractile front velocity and distal latency of esophageal peristaltic contractions were significantly changed during real stress, which was not observed during sham stress. GER parameters were not significantly altered during real stress and during sham stress. CONCLUSION: Although acute auditory and visual stress seems to affect esophageal body motility, it does not induce significant motor abnormalities or increase GER in healthy humans. Korean Society of Neurogastroenterology and Motility 2017-01 2017-01-01 /pmc/articles/PMC5216637/ /pubmed/28049863 http://dx.doi.org/10.5056/jnm16119 Text en © 2017 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Hong Sub Noh, Chung Kyun Lee, Kwang Jae The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans |
title | The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans |
title_full | The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans |
title_fullStr | The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans |
title_full_unstemmed | The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans |
title_short | The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans |
title_sort | effect of acute stress on esophageal motility and gastroesophageal reflux in healthy humans |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216637/ https://www.ncbi.nlm.nih.gov/pubmed/28049863 http://dx.doi.org/10.5056/jnm16119 |
work_keys_str_mv | AT leehongsub theeffectofacutestressonesophagealmotilityandgastroesophagealrefluxinhealthyhumans AT nohchungkyun theeffectofacutestressonesophagealmotilityandgastroesophagealrefluxinhealthyhumans AT leekwangjae theeffectofacutestressonesophagealmotilityandgastroesophagealrefluxinhealthyhumans AT leehongsub effectofacutestressonesophagealmotilityandgastroesophagealrefluxinhealthyhumans AT nohchungkyun effectofacutestressonesophagealmotilityandgastroesophagealrefluxinhealthyhumans AT leekwangjae effectofacutestressonesophagealmotilityandgastroesophagealrefluxinhealthyhumans |