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Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis
Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216673/ https://www.ncbi.nlm.nih.gov/pubmed/28111540 http://dx.doi.org/10.3389/fnins.2016.00603 |
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author | Conde-Sieira, Marta Soengas, José L. |
author_facet | Conde-Sieira, Marta Soengas, José L. |
author_sort | Conde-Sieira, Marta |
collection | PubMed |
description | Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine cells in several fish species), and intestine] locations whereas fatty acid sensors seem to be present in hypothalamus, liver and BB. Glucose and fatty acid sensing capacities relate to food intake regulation and metabolism in fish. Hypothalamus is as a signaling integratory center in a way that detection of increased levels of nutrients result in food intake inhibition through changes in the expression of anorexigenic and orexigenic neuropeptides. Moreover, central nutrient sensing modulates functions in the periphery since they elicit changes in hepatic metabolism as well as in hormone secretion to counter-regulate changes in nutrient levels detected in the CNS. At peripheral level, the direct nutrient detection in liver has a crucial role in homeostatic control of glucose and fatty acid whereas in BB and intestine nutrient sensing is probably involved in regulation of hormone secretion from endocrine cells. |
format | Online Article Text |
id | pubmed-5216673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52166732017-01-20 Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis Conde-Sieira, Marta Soengas, José L. Front Neurosci Neuroscience Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine cells in several fish species), and intestine] locations whereas fatty acid sensors seem to be present in hypothalamus, liver and BB. Glucose and fatty acid sensing capacities relate to food intake regulation and metabolism in fish. Hypothalamus is as a signaling integratory center in a way that detection of increased levels of nutrients result in food intake inhibition through changes in the expression of anorexigenic and orexigenic neuropeptides. Moreover, central nutrient sensing modulates functions in the periphery since they elicit changes in hepatic metabolism as well as in hormone secretion to counter-regulate changes in nutrient levels detected in the CNS. At peripheral level, the direct nutrient detection in liver has a crucial role in homeostatic control of glucose and fatty acid whereas in BB and intestine nutrient sensing is probably involved in regulation of hormone secretion from endocrine cells. Frontiers Media S.A. 2017-01-05 /pmc/articles/PMC5216673/ /pubmed/28111540 http://dx.doi.org/10.3389/fnins.2016.00603 Text en Copyright © 2017 Conde-Sieira and Soengas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Conde-Sieira, Marta Soengas, José L. Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis |
title | Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis |
title_full | Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis |
title_fullStr | Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis |
title_full_unstemmed | Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis |
title_short | Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis |
title_sort | nutrient sensing systems in fish: impact on food intake regulation and energy homeostasis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216673/ https://www.ncbi.nlm.nih.gov/pubmed/28111540 http://dx.doi.org/10.3389/fnins.2016.00603 |
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