C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms

C3G, a Guanine nucleotide Exchange Factor (GEF) for Rap1 and R-Ras, has been shown to play important roles in development and cancer. Previous studies determined that C3G regulates cell death through down-regulation of p38α MAPK activity. Here, we found that C3G knock-down in MEFs and HCT116 cells p...

Descripción completa

Detalles Bibliográficos
Autores principales: Priego, Neibla, Arechederra, María, Sequera, Celia, Bragado, Paloma, Vázquez-Carballo, Ana, Gutiérrez-Uzquiza, Álvaro, Martín-Granado, Víctor, Ventura, Juan José, Kazanietz, Marcelo G., Guerrero, Carmen, Porras, Almudena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216706/
https://www.ncbi.nlm.nih.gov/pubmed/27286263
http://dx.doi.org/10.18632/oncotarget.9911

Ejemplares similares

Ejemplares similares