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EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling
Cancer cells prefer glycolysis for energy metabolism, even when there is sufficient oxygen to make it unnecessary. This is called the Warburg effect, and it promotes tumorigenesis and malignant progression. In this study, we demonstrated that EZH2, a multifaceted oncogenic protein involved in tumor...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216711/ https://www.ncbi.nlm.nih.gov/pubmed/27259264 http://dx.doi.org/10.18632/oncotarget.9761 |
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author | Pang, Bo Zheng, Xiang-Rong Tian, Jing-xia Gao, Tai-hong Gu, Guang-yan Zhang, Rui Fu, Yi-Bing Pang, Qi Li, Xin-Gang Liu, Qian |
author_facet | Pang, Bo Zheng, Xiang-Rong Tian, Jing-xia Gao, Tai-hong Gu, Guang-yan Zhang, Rui Fu, Yi-Bing Pang, Qi Li, Xin-Gang Liu, Qian |
author_sort | Pang, Bo |
collection | PubMed |
description | Cancer cells prefer glycolysis for energy metabolism, even when there is sufficient oxygen to make it unnecessary. This is called the Warburg effect, and it promotes tumorigenesis and malignant progression. In this study, we demonstrated that EZH2, a multifaceted oncogenic protein involved in tumor proliferation, invasion and metastasis, promotes glioblastoma tumorigenesis and malignant progression through activation of the Warburg effect. We observed that HIF1α is a target of EZH2 whose activation is necessary for EZH2-mediated metabolic adaption, and that HIF1α is activated upon EZH2 overexpression. EZH2 suppressed expression of EAF2, which in turn upregulated HIF1α levels. We conclude from these results that EZH2 promotes tumorigenesis and malignant progression in part by activating glycolysis through an EAF2-HIF1α signaling axis. |
format | Online Article Text |
id | pubmed-5216711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52167112017-01-15 EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling Pang, Bo Zheng, Xiang-Rong Tian, Jing-xia Gao, Tai-hong Gu, Guang-yan Zhang, Rui Fu, Yi-Bing Pang, Qi Li, Xin-Gang Liu, Qian Oncotarget Research Paper Cancer cells prefer glycolysis for energy metabolism, even when there is sufficient oxygen to make it unnecessary. This is called the Warburg effect, and it promotes tumorigenesis and malignant progression. In this study, we demonstrated that EZH2, a multifaceted oncogenic protein involved in tumor proliferation, invasion and metastasis, promotes glioblastoma tumorigenesis and malignant progression through activation of the Warburg effect. We observed that HIF1α is a target of EZH2 whose activation is necessary for EZH2-mediated metabolic adaption, and that HIF1α is activated upon EZH2 overexpression. EZH2 suppressed expression of EAF2, which in turn upregulated HIF1α levels. We conclude from these results that EZH2 promotes tumorigenesis and malignant progression in part by activating glycolysis through an EAF2-HIF1α signaling axis. Impact Journals LLC 2016-06-01 /pmc/articles/PMC5216711/ /pubmed/27259264 http://dx.doi.org/10.18632/oncotarget.9761 Text en Copyright: © 2016 Pang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Pang, Bo Zheng, Xiang-Rong Tian, Jing-xia Gao, Tai-hong Gu, Guang-yan Zhang, Rui Fu, Yi-Bing Pang, Qi Li, Xin-Gang Liu, Qian EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling |
title | EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling |
title_full | EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling |
title_fullStr | EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling |
title_full_unstemmed | EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling |
title_short | EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling |
title_sort | ezh2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of eaf2-hif1α signaling |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216711/ https://www.ncbi.nlm.nih.gov/pubmed/27259264 http://dx.doi.org/10.18632/oncotarget.9761 |
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