Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma

EGFR-mutated lung adenocarcinomas routinely develop resistance to tyrosine kinase inhibitors (TKI). To better characterize the relative frequencies of the resistance mechanisms, we analyzed 48 EGFR-mutated TKI-resistant specimens from 41 patients. Next-generation sequencing of post-treatment specime...

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Detalles Bibliográficos
Autores principales: Belchis, Deborah A., Tseng, Li-Hui, Gniadek, Thomas, Haley, Lisa, Lokhandwala, Parvez, Illei, Peter, Gocke, Christopher D., Forde, Patrick, Brahmer, Julie, Askin, Frederic B., Eshleman, James R., Lin, Ming-Tseh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216719/
https://www.ncbi.nlm.nih.gov/pubmed/27304188
http://dx.doi.org/10.18632/oncotarget.9931

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