Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder

HuR, an RNA-binding protein, post-transcriptionally regulates nearly 4% of encoding proteins implicated in cell survival. Here we show that HuR is required for the efficacy of chemotherapies in urothelial carcinoma of the bladder. We identify pyrvinium pamoate, an FDA-approved anthelminthic drug, as...

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Detalles Bibliográficos
Autores principales: Guo, Jiawei, Lv, Jing, Chang, Siyu, Chen, Zhi, Lu, Weiqiang, Xu, Chuanliang, Liu, Mingyao, Pang, Xiufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216720/
https://www.ncbi.nlm.nih.gov/pubmed/27303922
http://dx.doi.org/10.18632/oncotarget.9932

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