Cargando…
Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses
CD44 is a well-recognized stem cell biomarker expressed in colon and gastric cancer. In order to identify whether CD44 mRNA could be used as a prognostic marker in colon and gastric cancer, bioinformatic analyses were used in this study. cBioPortal analysis and COSMIC analysis were used to explore t...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216740/ https://www.ncbi.nlm.nih.gov/pubmed/27323782 http://dx.doi.org/10.18632/oncotarget.9998 |
_version_ | 1782491971978264576 |
---|---|
author | Xia, Pu Xu, Xiao-Yan |
author_facet | Xia, Pu Xu, Xiao-Yan |
author_sort | Xia, Pu |
collection | PubMed |
description | CD44 is a well-recognized stem cell biomarker expressed in colon and gastric cancer. In order to identify whether CD44 mRNA could be used as a prognostic marker in colon and gastric cancer, bioinformatic analyses were used in this study. cBioPortal analysis and COSMIC analysis were used to explore the CD44 mutation. CD44 mRNA levels were evaluated by using SAGE Genie tools and Oncomine analysis. Kaplan-Meier Plotter was performed to identify the prognostic roles of CD44 mRNA in these two cancers. In this study, first, we found that low alteration frequency of CD44 mRNA in colon and gastric cancer. Second, the high CD44 mRNA level was found in colon and gastric cancer, and it correlated with a benign survival rate in gastric cancer. Third, CD4 and CD74 may be used as markers to predict the prognosis of colon and gastric cancer. However, the deep mechanism(s) of these results remains unclear, further studies have to be performed in the future. |
format | Online Article Text |
id | pubmed-5216740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52167402017-01-15 Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses Xia, Pu Xu, Xiao-Yan Oncotarget Research Paper CD44 is a well-recognized stem cell biomarker expressed in colon and gastric cancer. In order to identify whether CD44 mRNA could be used as a prognostic marker in colon and gastric cancer, bioinformatic analyses were used in this study. cBioPortal analysis and COSMIC analysis were used to explore the CD44 mutation. CD44 mRNA levels were evaluated by using SAGE Genie tools and Oncomine analysis. Kaplan-Meier Plotter was performed to identify the prognostic roles of CD44 mRNA in these two cancers. In this study, first, we found that low alteration frequency of CD44 mRNA in colon and gastric cancer. Second, the high CD44 mRNA level was found in colon and gastric cancer, and it correlated with a benign survival rate in gastric cancer. Third, CD4 and CD74 may be used as markers to predict the prognosis of colon and gastric cancer. However, the deep mechanism(s) of these results remains unclear, further studies have to be performed in the future. Impact Journals LLC 2016-06-14 /pmc/articles/PMC5216740/ /pubmed/27323782 http://dx.doi.org/10.18632/oncotarget.9998 Text en Copyright: © 2016 Xia and Xu http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xia, Pu Xu, Xiao-Yan Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses |
title | Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses |
title_full | Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses |
title_fullStr | Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses |
title_full_unstemmed | Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses |
title_short | Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses |
title_sort | prognostic significance of cd44 in human colon cancer and gastric cancer: evidence from bioinformatic analyses |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216740/ https://www.ncbi.nlm.nih.gov/pubmed/27323782 http://dx.doi.org/10.18632/oncotarget.9998 |
work_keys_str_mv | AT xiapu prognosticsignificanceofcd44inhumancoloncancerandgastriccancerevidencefrombioinformaticanalyses AT xuxiaoyan prognosticsignificanceofcd44inhumancoloncancerandgastriccancerevidencefrombioinformaticanalyses |