The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein

cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been impl...

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Autores principales: Ramos-Espiritu, Lavoisier, Diaz, Ana, Nardin, Charlee, Saviola, Anthony J., Shaw, Fiona, Plitt, Tamar, Yang, Xia, Wolchok, Jedd, Pirog, Edyta C., Desman, Garrett, Sboner, Andrea, Zhang, Tuo, Xiang, Jenny, Merghoub, Taha, Levin, Lonny R., Buck, Jochen, Zippin, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216745/
https://www.ncbi.nlm.nih.gov/pubmed/27323809
http://dx.doi.org/10.18632/oncotarget.10056
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author Ramos-Espiritu, Lavoisier
Diaz, Ana
Nardin, Charlee
Saviola, Anthony J.
Shaw, Fiona
Plitt, Tamar
Yang, Xia
Wolchok, Jedd
Pirog, Edyta C.
Desman, Garrett
Sboner, Andrea
Zhang, Tuo
Xiang, Jenny
Merghoub, Taha
Levin, Lonny R.
Buck, Jochen
Zippin, Jonathan H.
author_facet Ramos-Espiritu, Lavoisier
Diaz, Ana
Nardin, Charlee
Saviola, Anthony J.
Shaw, Fiona
Plitt, Tamar
Yang, Xia
Wolchok, Jedd
Pirog, Edyta C.
Desman, Garrett
Sboner, Andrea
Zhang, Tuo
Xiang, Jenny
Merghoub, Taha
Levin, Lonny R.
Buck, Jochen
Zippin, Jonathan H.
author_sort Ramos-Espiritu, Lavoisier
collection PubMed
description cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo. These data identify the metabolic/pH sensor soluble adenylyl cyclase as a previously unappreciated tumor suppressor protein.
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spelling pubmed-52167452017-01-15 The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein Ramos-Espiritu, Lavoisier Diaz, Ana Nardin, Charlee Saviola, Anthony J. Shaw, Fiona Plitt, Tamar Yang, Xia Wolchok, Jedd Pirog, Edyta C. Desman, Garrett Sboner, Andrea Zhang, Tuo Xiang, Jenny Merghoub, Taha Levin, Lonny R. Buck, Jochen Zippin, Jonathan H. Oncotarget Research Paper cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo. These data identify the metabolic/pH sensor soluble adenylyl cyclase as a previously unappreciated tumor suppressor protein. Impact Journals LLC 2016-06-15 /pmc/articles/PMC5216745/ /pubmed/27323809 http://dx.doi.org/10.18632/oncotarget.10056 Text en Copyright: © 2016 Ramos-Espiritu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ramos-Espiritu, Lavoisier
Diaz, Ana
Nardin, Charlee
Saviola, Anthony J.
Shaw, Fiona
Plitt, Tamar
Yang, Xia
Wolchok, Jedd
Pirog, Edyta C.
Desman, Garrett
Sboner, Andrea
Zhang, Tuo
Xiang, Jenny
Merghoub, Taha
Levin, Lonny R.
Buck, Jochen
Zippin, Jonathan H.
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
title The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
title_full The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
title_fullStr The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
title_full_unstemmed The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
title_short The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
title_sort metabolic/ph sensor soluble adenylyl cyclase is a tumor suppressor protein
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216745/
https://www.ncbi.nlm.nih.gov/pubmed/27323809
http://dx.doi.org/10.18632/oncotarget.10056
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