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Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer
Berberine is a plant-derived compound used in traditional Chinese medicine, which has been shown to inhibit cell proliferation and migration in breast cancer. On the other hand, vasodilator-stimulated phosphoprotein (VASP) promotes actin filament elongation and cell migration. We previously showed t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216765/ https://www.ncbi.nlm.nih.gov/pubmed/27322681 http://dx.doi.org/10.18632/oncotarget.9968 |
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author | Su, Ke Hu, Pengchao Wang, Xiaolan Kuang, Changchun Xiang, Qingmin Yang, Fang Xiang, Jin Zhu, Shan Wei, Lei Zhang, Jingwei |
author_facet | Su, Ke Hu, Pengchao Wang, Xiaolan Kuang, Changchun Xiang, Qingmin Yang, Fang Xiang, Jin Zhu, Shan Wei, Lei Zhang, Jingwei |
author_sort | Su, Ke |
collection | PubMed |
description | Berberine is a plant-derived compound used in traditional Chinese medicine, which has been shown to inhibit cell proliferation and migration in breast cancer. On the other hand, vasodilator-stimulated phosphoprotein (VASP) promotes actin filament elongation and cell migration. We previously showed that VASP is overexpressed in high-motility breast cancer cells. Here we investigated whether the anti-tumorigenic effects of berberine are mediated by binding VASP in basal-like breast cancer. Our results show that berberine suppresses proliferation and migration of MDA-MB-231 cells as well as tumor growth in MDA-MB-231 nude mouse xenografts. We also show that berberine binds to VASP, inducing changes in its secondary structure and inhibits actin polymerization. Our study reveals the mechanism underlying berberine's inhibition of cell proliferation and migration in basal-like breast cancer, highlighting the use of berberine as a potential adjuvant therapeutic agent. |
format | Online Article Text |
id | pubmed-5216765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52167652017-01-15 Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer Su, Ke Hu, Pengchao Wang, Xiaolan Kuang, Changchun Xiang, Qingmin Yang, Fang Xiang, Jin Zhu, Shan Wei, Lei Zhang, Jingwei Oncotarget Research Paper Berberine is a plant-derived compound used in traditional Chinese medicine, which has been shown to inhibit cell proliferation and migration in breast cancer. On the other hand, vasodilator-stimulated phosphoprotein (VASP) promotes actin filament elongation and cell migration. We previously showed that VASP is overexpressed in high-motility breast cancer cells. Here we investigated whether the anti-tumorigenic effects of berberine are mediated by binding VASP in basal-like breast cancer. Our results show that berberine suppresses proliferation and migration of MDA-MB-231 cells as well as tumor growth in MDA-MB-231 nude mouse xenografts. We also show that berberine binds to VASP, inducing changes in its secondary structure and inhibits actin polymerization. Our study reveals the mechanism underlying berberine's inhibition of cell proliferation and migration in basal-like breast cancer, highlighting the use of berberine as a potential adjuvant therapeutic agent. Impact Journals LLC 2016-06-13 /pmc/articles/PMC5216765/ /pubmed/27322681 http://dx.doi.org/10.18632/oncotarget.9968 Text en Copyright: © 2016 Su et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Su, Ke Hu, Pengchao Wang, Xiaolan Kuang, Changchun Xiang, Qingmin Yang, Fang Xiang, Jin Zhu, Shan Wei, Lei Zhang, Jingwei Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer |
title | Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer |
title_full | Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer |
title_fullStr | Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer |
title_full_unstemmed | Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer |
title_short | Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer |
title_sort | tumor suppressor berberine binds vasp to inhibit cell migration in basal-like breast cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216765/ https://www.ncbi.nlm.nih.gov/pubmed/27322681 http://dx.doi.org/10.18632/oncotarget.9968 |
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