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PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma
PiwiRNAs, small non-coding RNAs processed by Piwi proteins, are involved in maintaining genome stability in germline cells. Recently, piwiRNA expression has been identified in some tumors. We have examined the potential reactivation of the Piwi/piwiRNA pathway in classical Hodgkin lymphoma (cHL). We...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216777/ https://www.ncbi.nlm.nih.gov/pubmed/27329591 http://dx.doi.org/10.18632/oncotarget.10015 |
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author | Cordeiro, Anna Navarro, Alfons Gaya, Anna Díaz-Beyá, Marina Gonzalez-Farré, Blanca Castellano, Joan Josep Fuster, Dolors Martínez, Carmen Martínez, Antonio Monzó, Mariano |
author_facet | Cordeiro, Anna Navarro, Alfons Gaya, Anna Díaz-Beyá, Marina Gonzalez-Farré, Blanca Castellano, Joan Josep Fuster, Dolors Martínez, Carmen Martínez, Antonio Monzó, Mariano |
author_sort | Cordeiro, Anna |
collection | PubMed |
description | PiwiRNAs, small non-coding RNAs processed by Piwi proteins, are involved in maintaining genome stability in germline cells. Recently, piwiRNA expression has been identified in some tumors. We have examined the potential reactivation of the Piwi/piwiRNA pathway in classical Hodgkin lymphoma (cHL). We found that Piwi proteins and three selected piwiRNAs, including piR-651, were expressed in cHL patients and cell lines, indicating that the Piwi/piwiRNA pathway is active in cHL. Interestingly, low levels of piR-651 were associated with lack of complete response to first-line treatment, as well as shorter disease-free and overall survival in a cohort of 94 cHL patients. At diagnosis, piR-651 was underexpressed in cHL serum samples compared to healthy controls, while after complete remission, piR-651 levels increased to levels similar to healthy controls. This is the first evidence that piwiRNAs are active in tumor and serum samples and impact prognosis in cHL. |
format | Online Article Text |
id | pubmed-5216777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52167772017-01-15 PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma Cordeiro, Anna Navarro, Alfons Gaya, Anna Díaz-Beyá, Marina Gonzalez-Farré, Blanca Castellano, Joan Josep Fuster, Dolors Martínez, Carmen Martínez, Antonio Monzó, Mariano Oncotarget Research Paper PiwiRNAs, small non-coding RNAs processed by Piwi proteins, are involved in maintaining genome stability in germline cells. Recently, piwiRNA expression has been identified in some tumors. We have examined the potential reactivation of the Piwi/piwiRNA pathway in classical Hodgkin lymphoma (cHL). We found that Piwi proteins and three selected piwiRNAs, including piR-651, were expressed in cHL patients and cell lines, indicating that the Piwi/piwiRNA pathway is active in cHL. Interestingly, low levels of piR-651 were associated with lack of complete response to first-line treatment, as well as shorter disease-free and overall survival in a cohort of 94 cHL patients. At diagnosis, piR-651 was underexpressed in cHL serum samples compared to healthy controls, while after complete remission, piR-651 levels increased to levels similar to healthy controls. This is the first evidence that piwiRNAs are active in tumor and serum samples and impact prognosis in cHL. Impact Journals LLC 2016-06-14 /pmc/articles/PMC5216777/ /pubmed/27329591 http://dx.doi.org/10.18632/oncotarget.10015 Text en Copyright: © 2016 Cordeiro et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Cordeiro, Anna Navarro, Alfons Gaya, Anna Díaz-Beyá, Marina Gonzalez-Farré, Blanca Castellano, Joan Josep Fuster, Dolors Martínez, Carmen Martínez, Antonio Monzó, Mariano PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma |
title | PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma |
title_full | PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma |
title_fullStr | PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma |
title_full_unstemmed | PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma |
title_short | PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma |
title_sort | piwirna-651 as marker of treatment response and survival in classical hodgkin lymphoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216777/ https://www.ncbi.nlm.nih.gov/pubmed/27329591 http://dx.doi.org/10.18632/oncotarget.10015 |
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