CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements

There is an urgent need for the development of less toxic, more selective and targeted therapies for infants with leukemia characterized by translocation of the mixed lineage leukemia (MLL) gene. In this study, we performed a cell-based small molecule library screen on an infant MLL-rearranged (MLL-...

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Detalles Bibliográficos
Autores principales: Somers, Klaartje, Chudakova, Daria A., Middlemiss, Shiloh M.C., Wen, Victoria W., Clifton, Molly, Kwek, Alan, Liu, Bing, Mayoh, Chelsea, Bongers, Angelika, Karsa, Mawar, Pan, Sukey, Cruikshank, Sarah, Scandlyn, Marissa, Hoang, Wendi, Imamura, Toshihiko, Kees, Ursula R., Gudkov, Andrei V., Chernova, Olga B., Haber, Michelle, Norris, Murray D., Henderson, Michelle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216782/
https://www.ncbi.nlm.nih.gov/pubmed/27317766
http://dx.doi.org/10.18632/oncotarget.10022

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