Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways

Frizzled2 (FZD2) is a receptor for Wnts and may activate both canonical and non-canonical Wnt signaling pathways in cancer. However, no studies have reported an association between FZD2 signaling and high-risk NB so far. Here we report that FZD2 signaling pathways are critical to NB growth in MYCN-s...

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Detalles Bibliográficos
Autores principales: Zins, Karin, Schäfer, Romana, Paulus, Patrick, Dobler, Silvia, Fakhari, Nazak, Sioud, Mouldy, Aharinejad, Seyedhossein, Abraham, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216790/
https://www.ncbi.nlm.nih.gov/pubmed/27323822
http://dx.doi.org/10.18632/oncotarget.10070

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