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Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
Statin has been known not only as their cholesterol-lowering action but also on their pleiotropic effects including anti-inflammatory and anti-oxidant as well as anti-cancer effect. Nrf2 (NF-E2-related factor 2) is a transcription factor to activate cellular antioxidant response to oxidative stress....
Autores principales: | Jang, Hyun Joo, Hong, Eun Mi, Kim, Mikang, Kim, Jae Hyun, Jang, Juah, Park, Se Woo, Byun, Hyun Wu, Koh, Dong Hee, Choi, Min Ho, Kae, Sea Hyub, Lee, Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216792/ https://www.ncbi.nlm.nih.gov/pubmed/27323826 http://dx.doi.org/10.18632/oncotarget.10078 |
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