RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein

Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate that RING1B is highly expressed in primary ES tumors, and its expression is independent of the fusion oncogene. RING1B-depleted ES cells display an expression profile enriched in g...

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Detalles Bibliográficos
Autores principales: Hernandez-Muñoz, Inmaculada, Figuerola, Elisabeth, Sanchez-Molina, Sara, Rodriguez, Eva, Fernández-Mariño, Ana Isabel, Pardo-Pastor, Carlos, Bahamonde, María Isabel, Fernández-Fernández, José M., García-Domínguez, Daniel J., Hontecillas-Prieto, Lourdes, Lavarino, Cinzia, Carcaboso, Angel M., de Torres, Carmen, Tirado, Oscar M., de Alava, Enrique, Mora, Jaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216798/
https://www.ncbi.nlm.nih.gov/pubmed/27317769
http://dx.doi.org/10.18632/oncotarget.10092

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