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Disintegrin targeting of an α(v)β(3) integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro

The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses α(v)β(3) integrin. Echistatin is an RGD cyclic peptide and an antagonist of α(v)β(3) integrin. In the present study, echistatin inhibited cell prolif...

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Detalles Bibliográficos
Autores principales:	Tome, Yasunori, Kimura, Hiroaki, Kiyuna, Tasuku, Sugimoto, Naotoshi, Tsuchiya, Hiroyuki, Kanaya, Fuminori, Bouvet, Michael, Hoffman, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216800/ https://www.ncbi.nlm.nih.gov/pubmed/27331872 http://dx.doi.org/10.18632/oncotarget.10111

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