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Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer
Colorectal cancer remains a major public health problem worldwide. Despite the introduction of antiangiogenic drugs for the treatment of metastatic disease, a large number of issues remains unresolved. In particular, studies on predictive biomarkers of response and pathways of resistance to these ag...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216829/ https://www.ncbi.nlm.nih.gov/pubmed/27081084 http://dx.doi.org/10.18632/oncotarget.8712 |
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author | Ulivi, Paola Marisi, Giorgia Passardi, Alessandro |
author_facet | Ulivi, Paola Marisi, Giorgia Passardi, Alessandro |
author_sort | Ulivi, Paola |
collection | PubMed |
description | Colorectal cancer remains a major public health problem worldwide. Despite the introduction of antiangiogenic drugs for the treatment of metastatic disease, a large number of issues remains unresolved. In particular, studies on predictive biomarkers of response and pathways of resistance to these agents are lacking, making it difficult to accurately select candidates for treatment. Hypoxia is the prime driving force for tumor angiogenesis and a vicious cycle between hypoxia and angiogenesis can be observed in tumors. Anti-angiogenic drugs act inhibiting tumor vasculature and, as consequence, inducing hypoxia. However, hypoxia could, in turn, induce an increase of metastatic potential of cells and a series of phenomena that could induce drug resistance. In the present review biological mechanisms of hypoxia and its relation with angiogenesis, and resistance to antiangiogenic therapy will be discussed. Moreover, data from clinical trials on antiangiogenic drugs in metastatic colorectal cancer will be reviewed, and the role of hypoxia in monitoring the response to treatment will be analysed. Combination strategies using anti-angiogenic and hypoxia inhibiting drugs are also discussed as they constitute promising field of research. |
format | Online Article Text |
id | pubmed-5216829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52168292017-01-15 Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer Ulivi, Paola Marisi, Giorgia Passardi, Alessandro Oncotarget Review Colorectal cancer remains a major public health problem worldwide. Despite the introduction of antiangiogenic drugs for the treatment of metastatic disease, a large number of issues remains unresolved. In particular, studies on predictive biomarkers of response and pathways of resistance to these agents are lacking, making it difficult to accurately select candidates for treatment. Hypoxia is the prime driving force for tumor angiogenesis and a vicious cycle between hypoxia and angiogenesis can be observed in tumors. Anti-angiogenic drugs act inhibiting tumor vasculature and, as consequence, inducing hypoxia. However, hypoxia could, in turn, induce an increase of metastatic potential of cells and a series of phenomena that could induce drug resistance. In the present review biological mechanisms of hypoxia and its relation with angiogenesis, and resistance to antiangiogenic therapy will be discussed. Moreover, data from clinical trials on antiangiogenic drugs in metastatic colorectal cancer will be reviewed, and the role of hypoxia in monitoring the response to treatment will be analysed. Combination strategies using anti-angiogenic and hypoxia inhibiting drugs are also discussed as they constitute promising field of research. Impact Journals LLC 2016-04-12 /pmc/articles/PMC5216829/ /pubmed/27081084 http://dx.doi.org/10.18632/oncotarget.8712 Text en Copyright: © 2016 Ulivi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Ulivi, Paola Marisi, Giorgia Passardi, Alessandro Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer |
title | Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer |
title_full | Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer |
title_fullStr | Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer |
title_full_unstemmed | Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer |
title_short | Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer |
title_sort | relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216829/ https://www.ncbi.nlm.nih.gov/pubmed/27081084 http://dx.doi.org/10.18632/oncotarget.8712 |
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