Cargando…

Exploring conformational equilibria of a heterodimeric ABC transporter

ABC exporters pump substrates across the membrane by coupling ATP-driven movements of nucleotide binding domains (NBDs) to the transmembrane domains (TMDs), which switch between inward- and outward-facing (IF, OF) orientations. DEER measurements on the heterodimeric ABC exporter TM287/288 from Therm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Timachi, M Hadi, Hutter, Cedric AJ, Hohl, Michael, Assafa, Tufa, Böhm, Simon, Mittal, Anshumali, Seeger, Markus A, Bordignon, Enrica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216877/ https://www.ncbi.nlm.nih.gov/pubmed/28051765 http://dx.doi.org/10.7554/eLife.20236

Ejemplares similares

Mg(2+)-dependent conformational equilibria in CorA and an integrated view on transport regulation
por: Johansen, Nicolai Tidemand, et al.
Publicado: (2022)

The extracellular gate shapes the energy profile of an ABC exporter
por: Hutter, Cedric A. J., et al.
Publicado: (2019)

The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis
por: Hürlimann, Lea M., et al.
Publicado: (2016)

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein
por: Renner, Max, et al.
Publicado: (2016)

Structural and functional insights of the human peroxisomal ABC transporter ALDP
por: Jia, Yutian, et al.
Publicado: (2022)

Tuning the Drug Efflux Activity of an ABC Transporter in vivo by in vitro Selected DARPin Binders
por: Seeger, Markus A., et al.
Publicado: (2012)

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae
por: Leyrat, Cedric, et al.
Publicado: (2014)

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation
por: Kolich, Ljuvica R, et al.
Publicado: (2020)

Confirmation for conformational selection
por: Jiang, Yajun, et al.
Publicado: (2018)

Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses
por: Wang, Ling, et al.
Publicado: (2020)

Revealing an outward-facing open conformational state in a CLC Cl(–)/H(+) exchange transporter
por: Khantwal, Chandra M, et al.
Publicado: (2016)

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter
por: Mishra, Smriti, et al.
Publicado: (2014)

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
por: Tsutsumi, Naotaka, et al.
Publicado: (2020)

Conformation space of a heterodimeric ABC exporter under turnover conditions
por: Hofmann, Susanne, et al.
Publicado: (2019)

Sequential conformational rearrangements in flavivirus membrane fusion
por: Chao, Luke H, et al.
Publicado: (2014)

Asymmetric conformational maturation of HIV-1 reverse transcriptase
por: Zheng, Xunhai, et al.
Publicado: (2015)

Correction: Sequential conformational rearrangements in flavivirus membrane fusion
por: Chao, Luke H, et al.
Publicado: (2015)

Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter
por: Tang, Qingyu, et al.
Publicado: (2023)

Sampling the conformational space of the catalytic subunit of human γ-secretase
por: Bai, Xiao-chen, et al.
Publicado: (2015)

A conformational switch regulates the ubiquitin ligase HUWE1
por: Sander, Bodo, et al.
Publicado: (2017)

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography
por: Keedy, Daniel A, et al.
Publicado: (2015)

Identification of a pre-active conformation of a pentameric channel receptor
por: Menny, Anaïs, et al.
Publicado: (2017)

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
por: Simon, Márton A, et al.
Publicado: (2023)

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex
por: Vovk, Andrei, et al.
Publicado: (2016)

Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
por: Lee, Ho-Jin, et al.
Publicado: (2015)

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
por: Fung, Ho Yee Joyce, et al.
Publicado: (2017)

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles
por: Rosenzweig, Rina, et al.
Publicado: (2017)

Sampling alternative conformational states of transporters and receptors with AlphaFold2
por: del Alamo, Diego, et al.
Publicado: (2022)

Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition
por: Liu, Zhu, et al.
Publicado: (2015)

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
por: Geyer, Elisabeth A, et al.
Publicado: (2015)

Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states
por: Tan, Dan, et al.
Publicado: (2016)

Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex
por: Choi, Ucheor B, et al.
Publicado: (2016)

Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips
por: Driver, Jonathan W, et al.
Publicado: (2017)

The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells
por: Galazzo, Laura, et al.
Publicado: (2022)

Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch
por: Le, My-Tra, et al.
Publicado: (2017)

Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations
por: Leninger, Maureen, et al.
Publicado: (2019)

Exploring the conformational diversity of proteins
por: Schlessinger, Avner, et al.
Publicado: (2022)

Domain Motion in Cytochrome P450 Reductase: CONFORMATIONAL EQUILIBRIA REVEALED BY NMR AND SMALL-ANGLE X-RAY SCATTERING
por: Ellis, Jacqueline, et al.
Publicado: (2009)

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
por: Yu, Xiaodi, et al.
Publicado: (2019)

Ligand binding remodels protein side-chain conformational heterogeneity
por: Wankowicz, Stephanie A, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_utpiug6nm43vgpadt03amaub60