Cargando…

Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival

In humans, daylight vision is primarily mediated by cone photoreceptors. These cells die in age-related retinal degenerations. Prolonging the life of cones for even one decade would have an enormous beneficial effect on usable vision in an aging population. Photoreceptors are postmitotic, but shed 1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajala, Ammaji, Wang, Yuhong, Rajala, Raju V.S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216914/ https://www.ncbi.nlm.nih.gov/pubmed/27391439 http://dx.doi.org/10.18632/oncotarget.10447

Ejemplares similares

Developmental and light regulation of tumor suppressor protein PP2A in the retina
por: Rajala, Ammaji, et al.
Publicado: (2017)

Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration
por: Rajala, Ammaji, et al.
Publicado: (2018)

Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells
por: Gupta, Vivek K, et al.
Publicado: (2015)

Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation
por: Rajala, Raju VS, et al.
Publicado: (2013)

Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina
por: Rajala, Ammaji, et al.
Publicado: (2013)

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
por: Rajala, Ammaji, et al.
Publicado: (2022)

Loss of Class III Phosphoinositide 3-Kinase Vps34 Results in Cone Degeneration
por: Rajala, Ammaji, et al.
Publicado: (2020)

Phosphoinositides: Minor Lipids Make a Major Impact on Photoreceptor Cell Functions
por: Rajala, Raju V. S., et al.
Publicado: (2014)

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability
por: Rajala, Ammaji, et al.
Publicado: (2018)

Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14
por: Rajala, Raju V. S., et al.
Publicado: (2021)

Lipid Nanoparticles for Ocular Gene Delivery
por: Wang, Yuhong, et al.
Publicado: (2015)

The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina
por: Rajala, Raju V. S., et al.
Publicado: (2016)

Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy
por: Rajala, Ammaji, et al.
Publicado: (2020)

Cell-Specific Promoters Enable Lipid-Based Nanoparticles to Deliver Genes to Specific Cells of the Retina In Vivo
por: Wang, Yuhong, et al.
Publicado: (2016)

Effect of Knocking Down the Insulin Receptor on Mouse Rod Responses
por: Woodruff, Michael L., et al.
Publicado: (2015)

Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy
por: Zieger, Marina, et al.
Publicado: (2016)

Phosphoinositide Lipids in Ocular Tissues
por: Rajala, Ammaji, et al.
Publicado: (2020)

To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss
por: Kam, Jaimie Hoh, et al.
Publicado: (2015)

Octogenarians with EGFR-mutated non-small cell lung cancer treated by tyrosine-kinase inhibitor: a multicentric real-world study assessing tolerance and efficacy (OCTOMUT study)
por: Corre, Romain, et al.
Publicado: (2018)

Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells
por: Liu, Zhao, et al.
Publicado: (2016)

Atlas of phosphoinositide signatures in the retina identifies heterogeneity between cell types
por: Rajala, Ammaji, et al.
Publicado: (2023)

Wnt/β-catenin signaling promotes aging-associated hair graying in mice
por: Zhang, Zhihui, et al.
Publicado: (2017)

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
por: Cai, Xiaoyu, et al.
Publicado: (2016)

PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes
por: Chen, Yng-Tay, et al.
Publicado: (2015)

Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro
por: Wang, Han, et al.
Publicado: (2017)

Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFα
por: Sasaki, Norihiko, et al.
Publicado: (2017)

Nanoparticle-Assisted Targeted Delivery of Eye-Specific Genes to Eyes Significantly Improves the Vision of Blind Mice In Vivo
por: Rajala, Ammaji, et al.
Publicado: (2014)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans
por: Kumar, Neeraj, et al.
Publicado: (2015)

Downregulation of protein kinase CK2 activity induces age-related biomarkers in C. elegans
por: Park, Jeong-Hwan, et al.
Publicado: (2017)

Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans
por: Li, Yan-Hui, et al.
Publicado: (2016)

Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging
por: Rodriguez-Perez, Ana I., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_uodllgq0k4odif22odbol5jjkk