Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model

Ewing's sarcoma is a rare and aggressive malignancy. In the present study, tumor from a patient with a Ewing's sarcoma with cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) loss and FUS-ERG fusion was implanted in the right chest wall of nude mice to establish a patient-derived orthotopic...

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Detalles Bibliográficos
Autores principales: Murakami, Takashi, Singh, Arun S., Kiyuna, Tasuku, Dry, Sarah M., Li, Yunfeng, James, Aaron W., Igarashi, Kentaro, Kawaguchi, Kei, DeLong, Jonathan C., Zhang, Yong, Hiroshima, Yukihiko, Russell, Tara, Eckardt, Mark A., Yanagawa, Jane, Federman, Noah, Matsuyama, Ryusei, Chishima, Takashi, Tanaka, Kuniya, Bouvet, Michael, Endo, Itaru, Eilber, Fritz C., Hoffman, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216960/
https://www.ncbi.nlm.nih.gov/pubmed/27286459
http://dx.doi.org/10.18632/oncotarget.9879

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