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BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

mTOR activation is commonly caused by oncogenic mutations in RAS/RAF/MAPK and PI3K/AKT pathways, and promotes cancer progression and therapeutic resistance. However, mTOR inhibitors show limited single agent efficacy in patients. mTOR inhibitors suppress tumor cell growth and angiogenesis, and have...

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Detalles Bibliográficos
Autores principales:	He, Kan, Chen, Dongshi, Ruan, Hang, Li, Xiangyun, Tong, Jingshan, Xu, Xiang, Zhang, Lin, Yu, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216972/ https://www.ncbi.nlm.nih.gov/pubmed/27351224 http://dx.doi.org/10.18632/oncotarget.10277

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