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Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
KRAS mutation is often present in many hard-to-treat tumors such as colon and pancreatic cancer and it is tightly linked to serious alterations in the normal cell metabolism and clinical resistance to chemotherapy. In 1931, the winner of the Nobel Prize in Medicine, Otto Warburg, stated that cancer...
Autores principales: | Aguilera, Oscar, Muñoz-Sagastibelza, María, Torrejón, Blanca, Borrero-Palacios, Aurea, del Puerto-Nevado, Laura, Martínez-Useros, Javier, Rodriguez-Remirez, María, Zazo, Sandra, García, Estela, Fraga, Mario, Rojo, Federico, García-Foncillas, Jesús |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216991/ https://www.ncbi.nlm.nih.gov/pubmed/27323830 http://dx.doi.org/10.18632/oncotarget.10087 |
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