A p53-independent apoptotic mechanism of adenoviral mutant E1A was involved in its selective antitumor activity for human cancer

The conserved regions (CR) of adenoviral E1A had been shown to be necessary for disruption of pRb-E2F transcription factor complexes and induction of the S phase. Here we constructed a mutant adenoviral E1A with Rb-binding ability absent (E1A 30-60aa and 120-127aa deletion, mE1A) and investigated it...

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Detalles Bibliográficos
Autores principales: Fang, Lin, Cheng, Qian, Zhao, Jingjing, Ge, Yan, Zhu, Qi, Zhao, Min, Zhang, Jie, Zhang, Qi, Li, Liantao, Liu, Junjie, Zheng, Junnian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217019/
https://www.ncbi.nlm.nih.gov/pubmed/27340782
http://dx.doi.org/10.18632/oncotarget.10221

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