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PD1 blockade enhances cytotoxicity of in vitro expanded natural killer cells towards myeloma cells

Aiming for an adoptive natural killer (NK) cell therapy, we have developed a novel protocol to expand NK cells from peripheral blood. With this protocol using anti-human CD16 antibody and interleukin (IL)-2, NK (CD3(−)CD56(+)) cells could be expanded about 4000-fold with over 70% purity during a 21-...

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Detalles Bibliográficos
Autores principales:	Guo, Yanan, Feng, Xiaoli, Jiang, Yang, Shi, Xiaoyun, Xing, Xiangling, Liu, Xiaoli, Li, Nailin, Fadeel, Bengt, Zheng, Chengyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217023/ https://www.ncbi.nlm.nih.gov/pubmed/27356741 http://dx.doi.org/10.18632/oncotarget.10235

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