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Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study

BACKGROUND: Neurocognitive dysfunction is a critical target symptom of schizophrenia treatment. A positive correlation between physical activity level and neurocognitive function has been reported in healthy individuals, but it is unclear whether such a correlation exists in patients with schizophre...

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Autores principales: Kurebayashi, Yusuke, Otaki, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217227/
https://www.ncbi.nlm.nih.gov/pubmed/28056892
http://dx.doi.org/10.1186/s12888-016-1176-z
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author Kurebayashi, Yusuke
Otaki, Junichi
author_facet Kurebayashi, Yusuke
Otaki, Junichi
author_sort Kurebayashi, Yusuke
collection PubMed
description BACKGROUND: Neurocognitive dysfunction is a critical target symptom of schizophrenia treatment. A positive correlation between physical activity level and neurocognitive function has been reported in healthy individuals, but it is unclear whether such a correlation exists in patients with schizophrenia and whether the relationship is different according to inpatients or outpatients. This study aimed to examine the differences in the correlations between physical activity and multiple neurocognitive domains in inpatients and outpatients with schizophrenia and obtain suggestions for further study to facilitate this field. METHODS: Twenty-nine patients with schizophrenia were examined (16 inpatients and 13 outpatients, 56.0 ± 11.4 years of age). Current symptoms were assessed using the Positive and Negative Symptom Scale and neurocognitive functions using Cognitrax, which yields a composite neurocognitive index (NCI) and 11 domain scores. After testing, participants wore an HJA-750C accelerometer for one week to measure physical activity levels and durations. Partial correlation analyses were performed between exercise and cognitive parameters. RESULTS: In the outpatient group, higher physical activity was associated with faster Motor and Psychomotor Speeds in outpatients. However, higher physical activity was associated with lower overall NCI, Attention score, and Memory scores in inpatients. CONCLUSION: Although higher physical activity was associated with better neurocognitive functions of outpatients, in inpatients with non-remitted schizophrenia, higher physical activity was associated with worsening of several cognitive domains. In a future study examining the relationship between physical activity and neurocognitive function for facilitating this research field, separation between inpatients and outpatients are needed because the relationship is different between inpatients and outpatients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12888-016-1176-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-52172272017-01-09 Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study Kurebayashi, Yusuke Otaki, Junichi BMC Psychiatry Research Article BACKGROUND: Neurocognitive dysfunction is a critical target symptom of schizophrenia treatment. A positive correlation between physical activity level and neurocognitive function has been reported in healthy individuals, but it is unclear whether such a correlation exists in patients with schizophrenia and whether the relationship is different according to inpatients or outpatients. This study aimed to examine the differences in the correlations between physical activity and multiple neurocognitive domains in inpatients and outpatients with schizophrenia and obtain suggestions for further study to facilitate this field. METHODS: Twenty-nine patients with schizophrenia were examined (16 inpatients and 13 outpatients, 56.0 ± 11.4 years of age). Current symptoms were assessed using the Positive and Negative Symptom Scale and neurocognitive functions using Cognitrax, which yields a composite neurocognitive index (NCI) and 11 domain scores. After testing, participants wore an HJA-750C accelerometer for one week to measure physical activity levels and durations. Partial correlation analyses were performed between exercise and cognitive parameters. RESULTS: In the outpatient group, higher physical activity was associated with faster Motor and Psychomotor Speeds in outpatients. However, higher physical activity was associated with lower overall NCI, Attention score, and Memory scores in inpatients. CONCLUSION: Although higher physical activity was associated with better neurocognitive functions of outpatients, in inpatients with non-remitted schizophrenia, higher physical activity was associated with worsening of several cognitive domains. In a future study examining the relationship between physical activity and neurocognitive function for facilitating this research field, separation between inpatients and outpatients are needed because the relationship is different between inpatients and outpatients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12888-016-1176-z) contains supplementary material, which is available to authorized users. BioMed Central 2017-01-05 /pmc/articles/PMC5217227/ /pubmed/28056892 http://dx.doi.org/10.1186/s12888-016-1176-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kurebayashi, Yusuke
Otaki, Junichi
Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study
title Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study
title_full Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study
title_fullStr Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study
title_full_unstemmed Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study
title_short Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study
title_sort correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217227/
https://www.ncbi.nlm.nih.gov/pubmed/28056892
http://dx.doi.org/10.1186/s12888-016-1176-z
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