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Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1

BACKGROUND: Melanoma is a highly metastatic type of cancer that is resistant to all standard anticancer therapies and thus has a poor prognosis. Therefore, metastatic melanoma represents a significant clinical problem and requires novel and effective targeted therapies. The protein kinase C (PKC) fa...

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Detalles Bibliográficos
Autores principales:	Merzoug-Larabi, Messaouda, Spasojevic, Caroline, Eymard, Marianne, Hugonin, Caroline, Auclair, Christian, Karam, Manale
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217271/ https://www.ncbi.nlm.nih.gov/pubmed/28056869 http://dx.doi.org/10.1186/s12885-016-3007-5

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