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Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect

BACKGROUND: Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss hist...

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Autores principales: Tobouti, Priscila-Lie, Pigatti, Fernanda-Mombrini, Martins-Mussi, Maria-Carolina, Sedassari, Bruno-Tavares, Orsini-Machado de Sousa, Suzana-Cantanhede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217494/
https://www.ncbi.nlm.nih.gov/pubmed/27918739
http://dx.doi.org/10.4317/medoral.21401
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author Tobouti, Priscila-Lie
Pigatti, Fernanda-Mombrini
Martins-Mussi, Maria-Carolina
Sedassari, Bruno-Tavares
Orsini-Machado de Sousa, Suzana-Cantanhede
author_facet Tobouti, Priscila-Lie
Pigatti, Fernanda-Mombrini
Martins-Mussi, Maria-Carolina
Sedassari, Bruno-Tavares
Orsini-Machado de Sousa, Suzana-Cantanhede
author_sort Tobouti, Priscila-Lie
collection PubMed
description BACKGROUND: Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses. MATERIAL AND METHODS: We retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue. Immunohistochemical staining anti-S100 was also performed. RESULTS: The presented cases of Extra-tongue Oral Granular Cell Tumor (ETOGT) are composed by granular cells with intimately association with the adjacent tissue. Atypia and mitoses were not seen, and in most cases, the typical pseudoepitheliomatous hyperplasia was not observed. CONCLUSIONS: The importance of an adequate attention is to avoid misdiagnoses, since ETOGT is rare and the tricking histopathological findings could induce to it. All the cases can be differentiated from the tumors that has a granular cell proliferation through a morphological analysis and when needed, immunohistochemistry stain. Key words:Abrikossoff`s tumor, granular cell tumor, oral cavity.
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spelling pubmed-52174942017-01-09 Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect Tobouti, Priscila-Lie Pigatti, Fernanda-Mombrini Martins-Mussi, Maria-Carolina Sedassari, Bruno-Tavares Orsini-Machado de Sousa, Suzana-Cantanhede Med Oral Patol Oral Cir Bucal Research BACKGROUND: Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses. MATERIAL AND METHODS: We retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue. Immunohistochemical staining anti-S100 was also performed. RESULTS: The presented cases of Extra-tongue Oral Granular Cell Tumor (ETOGT) are composed by granular cells with intimately association with the adjacent tissue. Atypia and mitoses were not seen, and in most cases, the typical pseudoepitheliomatous hyperplasia was not observed. CONCLUSIONS: The importance of an adequate attention is to avoid misdiagnoses, since ETOGT is rare and the tricking histopathological findings could induce to it. All the cases can be differentiated from the tumors that has a granular cell proliferation through a morphological analysis and when needed, immunohistochemistry stain. Key words:Abrikossoff`s tumor, granular cell tumor, oral cavity. Medicina Oral S.L. 2017-01 2016-12-06 /pmc/articles/PMC5217494/ /pubmed/27918739 http://dx.doi.org/10.4317/medoral.21401 Text en Copyright: © 2017 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Tobouti, Priscila-Lie
Pigatti, Fernanda-Mombrini
Martins-Mussi, Maria-Carolina
Sedassari, Bruno-Tavares
Orsini-Machado de Sousa, Suzana-Cantanhede
Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect
title Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect
title_full Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect
title_fullStr Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect
title_full_unstemmed Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect
title_short Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect
title_sort extra-tongue oral granular cell tumor: histological and immunohistochemical aspect
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217494/
https://www.ncbi.nlm.nih.gov/pubmed/27918739
http://dx.doi.org/10.4317/medoral.21401
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