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Epiregulin as a therapeutic target in non-small-cell lung cancer

Epiregulin (EREG) belongs to the ErbB family of ligands. EREG binds to EGFR and ErbB4 receptor and stimulates homodimers of EGFR and ErbB4 in addition to all possible heterodimeric ErbB complexes, resulting in the activation of downstream signaling pathways. EREG is overexpressed in various human ca...

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Detalles Bibliográficos
Autores principales:	Sunaga, Noriaki, Kaira, Kyoichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217521/ https://www.ncbi.nlm.nih.gov/pubmed/28210154 http://dx.doi.org/10.2147/LCTT.S60427

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