Cargando…
Uniform Free-Energy Profiles of the P–O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ
[Image: see text] Human X-family DNA polymerases β (Polβ) and λ (Polλ) catalyze the nucleotidyl-transfer reaction in the base excision repair pathway of the cellular DNA damage response. Using empirical valence bond and free-energy perturbation simulations, we explore the feasibility of various mech...
Autores principales: | Klvaňa, Martin, Bren, Urban, Florián, Jan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2016
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217713/ https://www.ncbi.nlm.nih.gov/pubmed/27992186 http://dx.doi.org/10.1021/acs.jpcb.6b08581 |
Ejemplares similares
-
Aflatoxin B(1)–Formamidopyrimidine DNA Adducts: Relationships between Structures, Free Energies, and Melting Temperatures
por: Klvana, Martin, et al.
Publicado: (2019) -
Photoredox-catalyzed C–C bond cleavage of cyclopropanes for the formation of C(sp(3))–heteroatom bonds
por: Ge, Liang, et al.
Publicado: (2022) -
How the glycosyltransferase OGT catalyzes amide bond cleavage
por: Janetzko, John, et al.
Publicado: (2016) -
Graphene-catalyzed formation of C≡N bonds via cleavage of C-C and N-O bonds in ethanol and nitrate under room temperature
por: Xiao, Ding, et al.
Publicado: (2018) -
Potential Novel Thioether-Amide or Guanidine-Linker Class of SARS-CoV-2 Virus RNA-Dependent RNA Polymerase Inhibitors Identified by High-Throughput Virtual Screening Coupled to Free-Energy Calculations
por: Jukič, Marko, et al.
Publicado: (2021)