Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another

Here we describe how real-time label-free biosensors can be used to identify antibodies that compete for closely adjacent or minimally overlapping epitopes on their specific antigen via a mechanism of antibody displacement. By kinetically perturbing one another’s binding towards their antigen via th...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdiche, Yasmina Noubia, Yeung, Andy Yik, Ni, Irene, Stone, Donna, Miles, Adam, Morishige, Winse, Rossi, Andrea, Strop, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218414/
https://www.ncbi.nlm.nih.gov/pubmed/28060885
http://dx.doi.org/10.1371/journal.pone.0169535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218414/
https://www.ncbi.nlm.nih.gov/pubmed/28060885
http://dx.doi.org/10.1371/journal.pone.0169535

Ejemplares similares