Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography–mass s...

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Detalles Bibliográficos
Autores principales: Riethmueller, Steffen, Somasundaram, Prasath, Ehlers, Johanna C., Hung, Chien-Wen, Flynn, Charlotte M., Lokau, Juliane, Agthe, Maria, Düsterhöft, Stefan, Zhu, Yijue, Grötzinger, Joachim, Lorenzen, Inken, Koudelka, Tomas, Yamamoto, Kosuke, Pickhinke, Ute, Wichert, Rielana, Becker-Pauly, Christoph, Rädisch, Marisa, Albrecht, Alexander, Hessefort, Markus, Stahnke, Dominik, Unverzagt, Carlo, Rose-John, Stefan, Tholey, Andreas, Garbers, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218472/
https://www.ncbi.nlm.nih.gov/pubmed/28060820
http://dx.doi.org/10.1371/journal.pbio.2000080

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