Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations. Here we show that vein formation are disrupted in mouse skin and mesentery when Tie2 sign...

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Detalles Bibliográficos
Autores principales: Chu, Man, Li, Taotao, Shen, Bin, Cao, Xudong, Zhong, Haoyu, Zhang, Luqing, Zhou, Fei, Ma, Wenjuan, Jiang, Haijuan, Xie, Pancheng, Liu, Zhengzheng, Dong, Ningzheng, Xu, Ying, Zhao, Yun, Xu, Guoqiang, Lu, Peirong, Luo, Jincai, Wu, Qingyu, Alitalo, Kari, Koh, Gou Young, Adams, Ralf H, He, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218530/
https://www.ncbi.nlm.nih.gov/pubmed/28005008
http://dx.doi.org/10.7554/eLife.21032

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