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Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
Mg(2+) regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg(2+). Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg(2+) b...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218537/ https://www.ncbi.nlm.nih.gov/pubmed/27991852 http://dx.doi.org/10.7554/eLife.20914 |
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author | Chubanov, Vladimir Ferioli, Silvia Wisnowsky, Annika Simmons, David G Leitzinger, Christin Einer, Claudia Jonas, Wenke Shymkiv, Yuriy Bartsch, Harald Braun, Attila Akdogan, Banu Mittermeier, Lorenz Sytik, Ludmila Torben, Friedrich Jurinovic, Vindi van der Vorst, Emiel PC Weber, Christian Yildirim, Önder A Sotlar, Karl Schürmann, Annette Zierler, Susanna Zischka, Hans Ryazanov, Alexey G Gudermann, Thomas |
author_facet | Chubanov, Vladimir Ferioli, Silvia Wisnowsky, Annika Simmons, David G Leitzinger, Christin Einer, Claudia Jonas, Wenke Shymkiv, Yuriy Bartsch, Harald Braun, Attila Akdogan, Banu Mittermeier, Lorenz Sytik, Ludmila Torben, Friedrich Jurinovic, Vindi van der Vorst, Emiel PC Weber, Christian Yildirim, Önder A Sotlar, Karl Schürmann, Annette Zierler, Susanna Zischka, Hans Ryazanov, Alexey G Gudermann, Thomas |
author_sort | Chubanov, Vladimir |
collection | PubMed |
description | Mg(2+) regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg(2+). Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg(2+) balance during prenatal development and in adult mice by the ion channel TRPM6. We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic development. In adult mice, TRPM6 is required in the intestine to maintain organismal Mg(2+) balance, but is dispensable in the kidney. Trpm6 inactivation in adult mice leads to a shortened lifespan, growth deficit and metabolic alterations indicative of impaired energy balance. Dietary Mg(2+) supplementation not only rescues all phenotypes displayed by Trpm6-deficient adult mice, but also may extend the lifespan of wildtype mice. Hence, maintenance of organismal Mg(2+) balance by TRPM6 is crucial for prenatal development and survival to adulthood. DOI: http://dx.doi.org/10.7554/eLife.20914.001 |
format | Online Article Text |
id | pubmed-5218537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-52185372017-01-09 Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival Chubanov, Vladimir Ferioli, Silvia Wisnowsky, Annika Simmons, David G Leitzinger, Christin Einer, Claudia Jonas, Wenke Shymkiv, Yuriy Bartsch, Harald Braun, Attila Akdogan, Banu Mittermeier, Lorenz Sytik, Ludmila Torben, Friedrich Jurinovic, Vindi van der Vorst, Emiel PC Weber, Christian Yildirim, Önder A Sotlar, Karl Schürmann, Annette Zierler, Susanna Zischka, Hans Ryazanov, Alexey G Gudermann, Thomas eLife Biophysics and Structural Biology Mg(2+) regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg(2+). Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg(2+) balance during prenatal development and in adult mice by the ion channel TRPM6. We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic development. In adult mice, TRPM6 is required in the intestine to maintain organismal Mg(2+) balance, but is dispensable in the kidney. Trpm6 inactivation in adult mice leads to a shortened lifespan, growth deficit and metabolic alterations indicative of impaired energy balance. Dietary Mg(2+) supplementation not only rescues all phenotypes displayed by Trpm6-deficient adult mice, but also may extend the lifespan of wildtype mice. Hence, maintenance of organismal Mg(2+) balance by TRPM6 is crucial for prenatal development and survival to adulthood. DOI: http://dx.doi.org/10.7554/eLife.20914.001 eLife Sciences Publications, Ltd 2016-12-19 /pmc/articles/PMC5218537/ /pubmed/27991852 http://dx.doi.org/10.7554/eLife.20914 Text en © 2016, Chubanov et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Biophysics and Structural Biology Chubanov, Vladimir Ferioli, Silvia Wisnowsky, Annika Simmons, David G Leitzinger, Christin Einer, Claudia Jonas, Wenke Shymkiv, Yuriy Bartsch, Harald Braun, Attila Akdogan, Banu Mittermeier, Lorenz Sytik, Ludmila Torben, Friedrich Jurinovic, Vindi van der Vorst, Emiel PC Weber, Christian Yildirim, Önder A Sotlar, Karl Schürmann, Annette Zierler, Susanna Zischka, Hans Ryazanov, Alexey G Gudermann, Thomas Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival |
title | Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival |
title_full | Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival |
title_fullStr | Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival |
title_full_unstemmed | Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival |
title_short | Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival |
title_sort | epithelial magnesium transport by trpm6 is essential for prenatal development and adult survival |
topic | Biophysics and Structural Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218537/ https://www.ncbi.nlm.nih.gov/pubmed/27991852 http://dx.doi.org/10.7554/eLife.20914 |
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