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Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists

The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interactions and specific hy...

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Detalles Bibliográficos
Autores principales:	Lee, Sehan, Barron, Mace G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218732/ https://www.ncbi.nlm.nih.gov/pubmed/28061508 http://dx.doi.org/10.1371/journal.pone.0169607

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