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The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study

BACKGROUND: There may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine patients. METHODS: A total of 107 consecutive patients with migraine with (MA) and...

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Autores principales: Iwasaki, Akio, Suzuki, Keisuke, Takekawa, Hidehiro, Takashima, Ryotaro, Suzuki, Ayano, Suzuki, Shiho, Hirata, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218958/
https://www.ncbi.nlm.nih.gov/pubmed/28063107
http://dx.doi.org/10.1186/s10194-016-0714-x
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author Iwasaki, Akio
Suzuki, Keisuke
Takekawa, Hidehiro
Takashima, Ryotaro
Suzuki, Ayano
Suzuki, Shiho
Hirata, Koichi
author_facet Iwasaki, Akio
Suzuki, Keisuke
Takekawa, Hidehiro
Takashima, Ryotaro
Suzuki, Ayano
Suzuki, Shiho
Hirata, Koichi
author_sort Iwasaki, Akio
collection PubMed
description BACKGROUND: There may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine patients. METHODS: A total of 107 consecutive patients with migraine with (MA) and without aura (MWOA) were included in this study. Contrast transcranial Doppler ultrasound was used to detect RLs. WMLs were graded using brain magnetic resonance imaging based on well-established criteria. FINDINGS: The prevalence of RLs was significantly increased in the WMLs positive group (n = 24) compared with the WMLs negative group (n = 83) (75.0% vs. 47.0%, p = 0.015). In prevalence of WMLs between MA and MWOA patients, there were no statistical differences (p = 0.410). Logistic regression analysis adjusted by age and disease duration of migraine identified an RLs-positive status as the sole determinant for the presence of WMLs (OR = 6.15; 95% CI 1.82–20.8; p = 0.003) CONCLUSION: Our study suggests a possible link between RLs and WMLs in Japanese patients with migraine.
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spelling pubmed-52189582017-01-18 The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study Iwasaki, Akio Suzuki, Keisuke Takekawa, Hidehiro Takashima, Ryotaro Suzuki, Ayano Suzuki, Shiho Hirata, Koichi J Headache Pain Short Report BACKGROUND: There may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine patients. METHODS: A total of 107 consecutive patients with migraine with (MA) and without aura (MWOA) were included in this study. Contrast transcranial Doppler ultrasound was used to detect RLs. WMLs were graded using brain magnetic resonance imaging based on well-established criteria. FINDINGS: The prevalence of RLs was significantly increased in the WMLs positive group (n = 24) compared with the WMLs negative group (n = 83) (75.0% vs. 47.0%, p = 0.015). In prevalence of WMLs between MA and MWOA patients, there were no statistical differences (p = 0.410). Logistic regression analysis adjusted by age and disease duration of migraine identified an RLs-positive status as the sole determinant for the presence of WMLs (OR = 6.15; 95% CI 1.82–20.8; p = 0.003) CONCLUSION: Our study suggests a possible link between RLs and WMLs in Japanese patients with migraine. Springer Milan 2017-01-07 /pmc/articles/PMC5218958/ /pubmed/28063107 http://dx.doi.org/10.1186/s10194-016-0714-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Report
Iwasaki, Akio
Suzuki, Keisuke
Takekawa, Hidehiro
Takashima, Ryotaro
Suzuki, Ayano
Suzuki, Shiho
Hirata, Koichi
The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study
title The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study
title_full The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study
title_fullStr The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study
title_full_unstemmed The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study
title_short The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study
title_sort relationship between right-to-left shunt and brain white matter lesions in japanese patients with migraine: a single center study
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218958/
https://www.ncbi.nlm.nih.gov/pubmed/28063107
http://dx.doi.org/10.1186/s10194-016-0714-x
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