Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma

Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [(124)I] for a proof of concept study to assess the diagnostic accuracy of [(124)I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was ac...

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Detalles Bibliográficos
Autores principales: Green, Michael, Lowe, Jonathan, Kadirvel, Manikandan, McMahon, Adam, Westwood, Nigel, Chua, Sue, Brown, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219010/
https://www.ncbi.nlm.nih.gov/pubmed/28111488
http://dx.doi.org/10.1007/s10967-016-5073-1
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author Green, Michael
Lowe, Jonathan
Kadirvel, Manikandan
McMahon, Adam
Westwood, Nigel
Chua, Sue
Brown, Gavin
author_facet Green, Michael
Lowe, Jonathan
Kadirvel, Manikandan
McMahon, Adam
Westwood, Nigel
Chua, Sue
Brown, Gavin
author_sort Green, Michael
collection PubMed
description Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [(124)I] for a proof of concept study to assess the diagnostic accuracy of [(124)I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was achieved via the iododesilylation reaction between [(124)I]sodium iodide and meta-trimethylsilylbenzylguanidine. [(124)I]mIBG was produced in 62–70 % radioiodide incorporation yield from [(124)I]sodium iodide. The average amount of formulated [(124)I]mIBG was 359 MBq (range 344–389 MBq) with an average specific radioactivity of 4.1 TBq μmol(−1) (range 1.8–5.9 TBq μmol(−1)) at end of synthesis.
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spelling pubmed-52190102017-01-19 Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma Green, Michael Lowe, Jonathan Kadirvel, Manikandan McMahon, Adam Westwood, Nigel Chua, Sue Brown, Gavin J Radioanal Nucl Chem Article Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [(124)I] for a proof of concept study to assess the diagnostic accuracy of [(124)I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was achieved via the iododesilylation reaction between [(124)I]sodium iodide and meta-trimethylsilylbenzylguanidine. [(124)I]mIBG was produced in 62–70 % radioiodide incorporation yield from [(124)I]sodium iodide. The average amount of formulated [(124)I]mIBG was 359 MBq (range 344–389 MBq) with an average specific radioactivity of 4.1 TBq μmol(−1) (range 1.8–5.9 TBq μmol(−1)) at end of synthesis. Springer Netherlands 2016-10-24 2017 /pmc/articles/PMC5219010/ /pubmed/28111488 http://dx.doi.org/10.1007/s10967-016-5073-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Green, Michael
Lowe, Jonathan
Kadirvel, Manikandan
McMahon, Adam
Westwood, Nigel
Chua, Sue
Brown, Gavin
Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
title Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
title_full Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
title_fullStr Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
title_full_unstemmed Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
title_short Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
title_sort radiosynthesis of no-carrier-added meta-[(124)i]iodobenzylguanidine for pet imaging of metastatic neuroblastoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219010/
https://www.ncbi.nlm.nih.gov/pubmed/28111488
http://dx.doi.org/10.1007/s10967-016-5073-1
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