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Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression

Uncovering new therapeutic targets for renal fibrosis holds promise for the treatment of chronic kidney diseases. Bromodomain and extra-terminal (BET) protein inhibitors have been shown to effectively ameliorate pathological fibrotic responses. However, the pharmacological effects and underlying mec...

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Detalles Bibliográficos
Autores principales:	Zhou, Baoshang, Mu, Jiao, Gong, Yi, Lu, Caibao, Zhao, Youguang, He, Ting, Qin, Zhexue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219604/ https://www.ncbi.nlm.nih.gov/pubmed/28063381 http://dx.doi.org/10.1016/j.redox.2016.12.031

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