Assignment of polymorphic species of insulin analogues in ion mobility mass spectroscopy

Electrospray ionization – ion mobility spectrometry – mass spectrometry (ESI–IMS–MS) allows the identification of protein polymorphic distribution of protein conformers and oligomers. We report the detailed identification of the species observed with commercially available pharmaceutical preparation...

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Detalles Bibliográficos
Autores principales: Fávero-Retto, Maely P., Guerreiro, Luiz Henrique, Pessanha, Cássio M., Palmieri, Leonardo C., Lima, Luís Maurício T.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219646/
https://www.ncbi.nlm.nih.gov/pubmed/28070541
http://dx.doi.org/10.1016/j.dib.2016.12.020
Descripción
Sumario:Electrospray ionization – ion mobility spectrometry – mass spectrometry (ESI–IMS–MS) allows the identification of protein polymorphic distribution of protein conformers and oligomers. We report the detailed identification of the species observed with commercially available pharmaceutical preparation of wild-type, regular human insulin.

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