Cargando…

Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

BACKGROUND: Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aerobic glycolysis presents a promising strategy for cancer therapy. This study inv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hui-Min, Yang, Jie-Gang, Liu, Zhuo-Jue, Wang, Wei-Ming, Yu, Zi-Li, Ren, Jian-Gang, Chen, Gang, Zhang, Wei, Jia, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219669/ https://www.ncbi.nlm.nih.gov/pubmed/28061878 http://dx.doi.org/10.1186/s13046-016-0481-1

Ejemplares similares

Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
por: Yang, Kaiying, et al.
Publicado: (2023)

Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth
por: Hu, Jiahao, et al.
Publicado: (2022)

Role of PFKFB3-driven glycolysis in sepsis
por: Xiao, Min, et al.
Publicado: (2023)

miR-1297 Suppresses Osteosarcoma Proliferation and Aerobic Glycolysis by Regulating PFKFB2
por: Pan, Xiaohui, et al.
Publicado: (2020)

Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response
por: Zeng, Hao, et al.
Publicado: (2022)

MicroRNA-3666 Suppresses Cell Growth in Head and Neck Squamous Cell Carcinoma Through Inhibition of PFKFB3-Mediated Warburg Effect
por: Chen, Lan, et al.
Publicado: (2020)

Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
por: Yang, Qiuhua, et al.
Publicado: (2023)

Suppression of myeloid PFKFB3‐driven glycolysis protects mice from choroidal neovascularization
por: Liu, Zhiping, et al.
Publicado: (2022)

PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis
por: Yang, Qiuhua, et al.
Publicado: (2023)

Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis
por: Wang, Yanting, et al.
Publicado: (2021)

Effect of Opioid Receptor Activation and Blockage on the Progression and Response to Treatment of Head and Neck Squamous Cell Carcinoma
por: Levi, Lirit, et al.
Publicado: (2023)

HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression
por: Wang, Yixin, et al.
Publicado: (2021)

Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma
por: Li, Jun, et al.
Publicado: (2022)

Mir‐488 alleviates chemoresistance and glycolysis of colorectal cancer by targeting PFKFB3
por: Deng, Xiaojing, et al.
Publicado: (2020)

PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb
por: Ryan, Terence E., et al.
Publicado: (2020)

Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis
por: Lu, Chao, et al.
Publicado: (2022)

Identification of Prognostic Markers for Head and NeckSquamous Cell Carcinoma Based on Glycolysis-Related Genes
por: Ren, Xiaobin, et al.
Publicado: (2022)

Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer
por: Lu, Chao, et al.
Publicado: (2021)

Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma
por: Zhang, H, et al.
Publicado: (2008)

HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma
por: Zhang, Hongbo, et al.
Publicado: (2022)

Involvement of PFKFB3 in Pulmonary Arterial Hypertension Pathogenesis. Is It All about Glycolysis?
por: Bonnet, Sebastien, et al.
Publicado: (2019)

Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
por: Chen, Weimou, et al.
Publicado: (2021)

The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition
por: Emini Veseli, Besa, et al.
Publicado: (2021)

Phosphorylation of PPARγ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4
por: Shu, Yuxin, et al.
Publicado: (2016)

Theaflavins suppress tumor growth and metastasis via the blockage of the STAT3 pathway in hepatocellular carcinoma
por: Shao, Jianping, et al.
Publicado: (2016)

CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2
por: Qu, Juan, et al.
Publicado: (2020)

The metabolic role of PFKFB4 in androgen-independent growth in vitro and PFKFB4 expression in human prostate cancer tissue
por: Li, Ximing, et al.
Publicado: (2020)

The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma
por: Jiang, Man, et al.
Publicado: (2021)

MicroRNA‐488 inhibits proliferation and glycolysis in human prostate cancer cells by regulating PFKFB3
por: Wang, Jun, et al.
Publicado: (2019)

Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma
por: Gao, Lu, et al.
Publicado: (2018)

Long noncoding RNA LINC00930 promotes PFKFB3-mediated tumor glycolysis and cell proliferation in nasopharyngeal carcinoma
por: He, Baoyu, et al.
Publicado: (2022)

Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
por: Takahashi, Hideyuki, et al.
Publicado: (2021)

Transcriptome analysis reveals the prognostic and immune infiltration characteristics of glycolysis and hypoxia in head and neck squamous cell carcinoma
por: Liu, Jun, et al.
Publicado: (2022)

Survival Outcomes and Treatment Decision by Human Papillomavirus Status Among Patients With Stage IVC Head and Neck Squamous Cell Carcinoma
por: Zhou, Ping, et al.
Publicado: (2021)

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
por: Rodriguez-Rodriguez, P, et al.
Publicado: (2012)

Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation
por: Zhou, Zhou, et al.
Publicado: (2022)

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
por: Li, Fu-Long, et al.
Publicado: (2018)

Identification of the Nerve-Cancer Cross-Talk-Related Prognostic Gene Model in Head and Neck Squamous Cell Carcinoma
por: Li, Jun, et al.
Publicado: (2021)

Combination therapy with oncolytic viruses and immune checkpoint inhibitors in head and neck squamous cell carcinomas: an approach of complementary advantages
por: Dong, Hui, et al.
Publicado: (2023)

Decreased expression of GRIM-19 by DNA hypermethylation promotes aerobic glycolysis and cell proliferation in head and neck squamous cell carcinoma
por: Zhang, Xiao-Yun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_tb29qj291ncohuq08jk1n9svgl