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Effects of metabolic syndrome on aortic pulse wave velocity
BACKGROUND: The purpose of this study was to compare the value and evaluate the validity of non-invasive methods for the detection of vascular stiffness in never-treated individuals with metabolic syndrome (MetS). METHODS: A total of 59 subjects (mean age, 60 ± 12 years; male:female = 35:24) were en...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219709/ https://www.ncbi.nlm.nih.gov/pubmed/28074153 http://dx.doi.org/10.1186/s40885-016-0057-6 |
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author | Lee, Dong-Hyeon Youn, Ho-Joong Chung, Woo-Baek Choi, Yun-Seok Lee, Jong-Min Park, Chul-Soo Jung, Hae-Ok Jeon, Hui-Kyung Lee, Man-Young |
author_facet | Lee, Dong-Hyeon Youn, Ho-Joong Chung, Woo-Baek Choi, Yun-Seok Lee, Jong-Min Park, Chul-Soo Jung, Hae-Ok Jeon, Hui-Kyung Lee, Man-Young |
author_sort | Lee, Dong-Hyeon |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to compare the value and evaluate the validity of non-invasive methods for the detection of vascular stiffness in never-treated individuals with metabolic syndrome (MetS). METHODS: A total of 59 subjects (mean age, 60 ± 12 years; male:female = 35:24) were enrolled in the study and were categorized into the positive MetS (MetS[+]: N = 32) and negative group (MetS[−]: N = 27), according to the parameters set by the National Cholesterol Education Program’s Adult Treatment Panel III. Pulse wave velocity (PWV) of the aorta, arm, and leg, Framingham risk score (FRS), ankle-brachial index (ABI), and carotid intima-media thickness (IMT) for vascular aging were measured for the two groups. RESULTS: Aortic PWV (PWVaor) was significantly higher in MetS(+) than MetS(−) group (7.0 ± 1.4 m/s vs. 8.4 ± 1.6 m/s, p < 0.01), while ABI was significantly lower in MetS(+) than MetS(−) group (1.2 ± 0.1 vs. 1.1 ± 0.2, p = 0.03), respectively. FRS was significantly higher in MetS(+) than MetS(−) group (11 ± 5 vs. 14 ± 4, p = 0.05). The both mean IMT was higher in MetS(+) than MetS(−) group (right: 0.94 ± 0.20 mm vs. 0.81 ± 0.20 mm, p = 0.03; left: 0.93 ± 0.20 mm vs. 0.79 ± 0.20 mm, p = 0.03, respectively). For predicting the probability of the presence of MetS, PWVaor was an independent tool (p = 0.04; odds ratio, 1.88; 95% confidence interval, 1.03 to 3.42) and a cut-off value of PWVaor of 7.4 m/s showed a sensitivity of 66.7% and a specificity of 47.6%. CONCLUSIONS: We suggest that PWVaor, combined with traditional tools, can play an important role as a complementary or alternative tool for the detection of vascular stiffness in never-treated individuals with MetS. |
format | Online Article Text |
id | pubmed-5219709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52197092017-01-10 Effects of metabolic syndrome on aortic pulse wave velocity Lee, Dong-Hyeon Youn, Ho-Joong Chung, Woo-Baek Choi, Yun-Seok Lee, Jong-Min Park, Chul-Soo Jung, Hae-Ok Jeon, Hui-Kyung Lee, Man-Young Clin Hypertens Research BACKGROUND: The purpose of this study was to compare the value and evaluate the validity of non-invasive methods for the detection of vascular stiffness in never-treated individuals with metabolic syndrome (MetS). METHODS: A total of 59 subjects (mean age, 60 ± 12 years; male:female = 35:24) were enrolled in the study and were categorized into the positive MetS (MetS[+]: N = 32) and negative group (MetS[−]: N = 27), according to the parameters set by the National Cholesterol Education Program’s Adult Treatment Panel III. Pulse wave velocity (PWV) of the aorta, arm, and leg, Framingham risk score (FRS), ankle-brachial index (ABI), and carotid intima-media thickness (IMT) for vascular aging were measured for the two groups. RESULTS: Aortic PWV (PWVaor) was significantly higher in MetS(+) than MetS(−) group (7.0 ± 1.4 m/s vs. 8.4 ± 1.6 m/s, p < 0.01), while ABI was significantly lower in MetS(+) than MetS(−) group (1.2 ± 0.1 vs. 1.1 ± 0.2, p = 0.03), respectively. FRS was significantly higher in MetS(+) than MetS(−) group (11 ± 5 vs. 14 ± 4, p = 0.05). The both mean IMT was higher in MetS(+) than MetS(−) group (right: 0.94 ± 0.20 mm vs. 0.81 ± 0.20 mm, p = 0.03; left: 0.93 ± 0.20 mm vs. 0.79 ± 0.20 mm, p = 0.03, respectively). For predicting the probability of the presence of MetS, PWVaor was an independent tool (p = 0.04; odds ratio, 1.88; 95% confidence interval, 1.03 to 3.42) and a cut-off value of PWVaor of 7.4 m/s showed a sensitivity of 66.7% and a specificity of 47.6%. CONCLUSIONS: We suggest that PWVaor, combined with traditional tools, can play an important role as a complementary or alternative tool for the detection of vascular stiffness in never-treated individuals with MetS. BioMed Central 2017-01-06 /pmc/articles/PMC5219709/ /pubmed/28074153 http://dx.doi.org/10.1186/s40885-016-0057-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Lee, Dong-Hyeon Youn, Ho-Joong Chung, Woo-Baek Choi, Yun-Seok Lee, Jong-Min Park, Chul-Soo Jung, Hae-Ok Jeon, Hui-Kyung Lee, Man-Young Effects of metabolic syndrome on aortic pulse wave velocity |
title | Effects of metabolic syndrome on aortic pulse wave velocity |
title_full | Effects of metabolic syndrome on aortic pulse wave velocity |
title_fullStr | Effects of metabolic syndrome on aortic pulse wave velocity |
title_full_unstemmed | Effects of metabolic syndrome on aortic pulse wave velocity |
title_short | Effects of metabolic syndrome on aortic pulse wave velocity |
title_sort | effects of metabolic syndrome on aortic pulse wave velocity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219709/ https://www.ncbi.nlm.nih.gov/pubmed/28074153 http://dx.doi.org/10.1186/s40885-016-0057-6 |
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