Cargando…
MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes
Obesity is a causal factor of type 2 diabetes (T2D); however, people without obesity (including lean, normal weight, or overweight) may still develop T2D. Non-obese T2D is prevalent in Asia and also frequently occurs in Europe. Recently, multiple evidences oppose the notion that either obesity or ce...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219747/ https://www.ncbi.nlm.nih.gov/pubmed/28061846 http://dx.doi.org/10.1186/s12929-016-0307-7 |
_version_ | 1782492515729932288 |
---|---|
author | Chuang, Huai-Chia Tan, Tse-Hua |
author_facet | Chuang, Huai-Chia Tan, Tse-Hua |
author_sort | Chuang, Huai-Chia |
collection | PubMed |
description | Obesity is a causal factor of type 2 diabetes (T2D); however, people without obesity (including lean, normal weight, or overweight) may still develop T2D. Non-obese T2D is prevalent in Asia and also frequently occurs in Europe. Recently, multiple evidences oppose the notion that either obesity or central obesity (visceral fat accumulation) promotes non-obese T2D. Several factors such as inflammation and environmental factors contribute to non-obese T2D. According to the data derived from gene knockout mice and T2D clinical samples in Asia and Europe, the pathogenesis of non-obese T2D has been unveiled recently. MAP4K4 downregulation in T cells results in enhancement of the IL-6(+) Th17 cell population, leading to insulin resistance and T2D in both human and mice. Moreover, MAP4K4 single nucleotide polymorphisms and epigenetic changes are associated with T2D patients. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D. Future investigations of the pathogenesis of non-obese T2D shall lead to development of precision medicine for non-obese T2D. |
format | Online Article Text |
id | pubmed-5219747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52197472017-01-10 MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes Chuang, Huai-Chia Tan, Tse-Hua J Biomed Sci Review Obesity is a causal factor of type 2 diabetes (T2D); however, people without obesity (including lean, normal weight, or overweight) may still develop T2D. Non-obese T2D is prevalent in Asia and also frequently occurs in Europe. Recently, multiple evidences oppose the notion that either obesity or central obesity (visceral fat accumulation) promotes non-obese T2D. Several factors such as inflammation and environmental factors contribute to non-obese T2D. According to the data derived from gene knockout mice and T2D clinical samples in Asia and Europe, the pathogenesis of non-obese T2D has been unveiled recently. MAP4K4 downregulation in T cells results in enhancement of the IL-6(+) Th17 cell population, leading to insulin resistance and T2D in both human and mice. Moreover, MAP4K4 single nucleotide polymorphisms and epigenetic changes are associated with T2D patients. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D. Future investigations of the pathogenesis of non-obese T2D shall lead to development of precision medicine for non-obese T2D. BioMed Central 2017-01-07 /pmc/articles/PMC5219747/ /pubmed/28061846 http://dx.doi.org/10.1186/s12929-016-0307-7 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Chuang, Huai-Chia Tan, Tse-Hua MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes |
title | MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes |
title_full | MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes |
title_fullStr | MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes |
title_full_unstemmed | MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes |
title_short | MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes |
title_sort | map4k4 and il-6(+) th17 cells play important roles in non-obese type 2 diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219747/ https://www.ncbi.nlm.nih.gov/pubmed/28061846 http://dx.doi.org/10.1186/s12929-016-0307-7 |
work_keys_str_mv | AT chuanghuaichia map4k4andil6th17cellsplayimportantrolesinnonobesetype2diabetes AT tantsehua map4k4andil6th17cellsplayimportantrolesinnonobesetype2diabetes |