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DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

BACKGROUND: Interactions between genes and environment are critical factors for causing cancer in humans. The genotoxicity of environmental chemicals can be enhanced via the modulation of susceptible genes in host human cells. DNA polymerase kappa (Pol κ) is a specialized DNA polymerase that plays a...

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Detalles Bibliográficos
Autores principales:	Kanemaru, Yuki, Suzuki, Tetsuya, Sassa, Akira, Matsumoto, Kyomu, Adachi, Noritaka, Honma, Masamitsu, Numazawa, Satoshi, Nohmi, Takehiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219776/ https://www.ncbi.nlm.nih.gov/pubmed/28077981 http://dx.doi.org/10.1186/s41021-016-0067-3

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