Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

TCF3-PBX1 (E2A-PBX1) is a recurrent gene fusion in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is caused by the translocation t(1;19)(q23;p13). TCF3-PBX1 BCP-ALL patients typically benefit from chemotherapy; however, many relapse and subsequently develop resistant disease with few...

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Detalles Bibliográficos
Autores principales: Eldfors, S, Kuusanmäki, H, Kontro, M, Majumder, M M, Parsons, A, Edgren, H, Pemovska, T, Kallioniemi, O, Wennerberg, K, Gökbuget, N, Burmeister, T, Porkka, K, Heckman, C A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220125/
https://www.ncbi.nlm.nih.gov/pubmed/27461063
http://dx.doi.org/10.1038/leu.2016.202

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