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Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study
BACKGROUND: Restrictive spirometric pattern is a risk factor for all-cause and cause-specific mortality. OBJECTIVE: We assessed the prevalence of restrictive pattern and investigated its determinants in a major sub-Saharan Africa city. METHODS: Participants were adults (≥ 19 years) who took part in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220179/ https://www.ncbi.nlm.nih.gov/pubmed/28144367 http://dx.doi.org/10.2174/1874306401610010086 |
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author | Pefura-Yone, Eric Walter Balkissou, Adamou Dodo Kengne, Andre Pascal |
author_facet | Pefura-Yone, Eric Walter Balkissou, Adamou Dodo Kengne, Andre Pascal |
author_sort | Pefura-Yone, Eric Walter |
collection | PubMed |
description | BACKGROUND: Restrictive spirometric pattern is a risk factor for all-cause and cause-specific mortality. OBJECTIVE: We assessed the prevalence of restrictive pattern and investigated its determinants in a major sub-Saharan Africa city. METHODS: Participants were adults (≥ 19 years) who took part in a population-based survey in Yaounde (Cameroon) between December 2013 and April 2014. Restrictive pattern was based on a FVC below the lower limit of the normal (LLN) and a ratio forced expiratory volume in one second (FEV1)/FVC ≥ LLN (LLN-based restrictive pattern) or a FVC <80% and FEV1/FVC ≥ LLN (fixed cut-off based restrictive pattern). Determinants were investigated by logistic regressions. RESULTS: In all, 1003 participants [514 (51.2%) women] with a mean age of 33.7 years were included. The prevalence of restrictive pattern was 18.8% (95%CI: 16.6-21.2) based on LLN and 15.0% (13.0-17.2) based on fixed cut-off. LLN-based restrictive pattern was mild in 148 (78.3%) subjects, moderate in 35 (18.5%) and severe in 6 (3.2%). Determinants of LLN-based restrictive pattern were age ≥ 60 years [adjusted odds ratio 2.90 (95%CI 1.46-5.77), p=0.002), history of pulmonary tuberculosis [3.81(1.42-10.20), p=0.008], prevalent heart diseases [3.81 (1.20-12.12), p=0.024] and underweight [5.15(1.30-20.39), p=0.020]. Determinants were largely similar with slightly different effect sizes for fixed cut-off based restrictive pattern. CONCLUSION: Restrictive pattern was very frequent in this city. CLINICAL IMPLICATIONS: These results enhance the needs to increase the efforts to prevent and control tuberculosis, cardiovascular diseases and underweight in this setting. |
format | Online Article Text |
id | pubmed-5220179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-52201792017-01-31 Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study Pefura-Yone, Eric Walter Balkissou, Adamou Dodo Kengne, Andre Pascal Open Respir Med J Article BACKGROUND: Restrictive spirometric pattern is a risk factor for all-cause and cause-specific mortality. OBJECTIVE: We assessed the prevalence of restrictive pattern and investigated its determinants in a major sub-Saharan Africa city. METHODS: Participants were adults (≥ 19 years) who took part in a population-based survey in Yaounde (Cameroon) between December 2013 and April 2014. Restrictive pattern was based on a FVC below the lower limit of the normal (LLN) and a ratio forced expiratory volume in one second (FEV1)/FVC ≥ LLN (LLN-based restrictive pattern) or a FVC <80% and FEV1/FVC ≥ LLN (fixed cut-off based restrictive pattern). Determinants were investigated by logistic regressions. RESULTS: In all, 1003 participants [514 (51.2%) women] with a mean age of 33.7 years were included. The prevalence of restrictive pattern was 18.8% (95%CI: 16.6-21.2) based on LLN and 15.0% (13.0-17.2) based on fixed cut-off. LLN-based restrictive pattern was mild in 148 (78.3%) subjects, moderate in 35 (18.5%) and severe in 6 (3.2%). Determinants of LLN-based restrictive pattern were age ≥ 60 years [adjusted odds ratio 2.90 (95%CI 1.46-5.77), p=0.002), history of pulmonary tuberculosis [3.81(1.42-10.20), p=0.008], prevalent heart diseases [3.81 (1.20-12.12), p=0.024] and underweight [5.15(1.30-20.39), p=0.020]. Determinants were largely similar with slightly different effect sizes for fixed cut-off based restrictive pattern. CONCLUSION: Restrictive pattern was very frequent in this city. CLINICAL IMPLICATIONS: These results enhance the needs to increase the efforts to prevent and control tuberculosis, cardiovascular diseases and underweight in this setting. Bentham Open 2016-11-30 /pmc/articles/PMC5220179/ /pubmed/28144367 http://dx.doi.org/10.2174/1874306401610010086 Text en © Pefura-Yone et al.; Licensee Bentham Open. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Pefura-Yone, Eric Walter Balkissou, Adamou Dodo Kengne, Andre Pascal Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study |
title | Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study |
title_full | Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study |
title_fullStr | Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study |
title_full_unstemmed | Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study |
title_short | Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study |
title_sort | determinants of restrictive spirometric pattern in a sub-saharan urban setting: a cross-sectional population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220179/ https://www.ncbi.nlm.nih.gov/pubmed/28144367 http://dx.doi.org/10.2174/1874306401610010086 |
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